升白细胞治疗方案对急疹并发粒细胞缺乏症患儿的效果观察  

Effect of leukocytes elevating therapy on treatment of subitum children with agranulocytosis

作　　者：孔宪玲[1] 林国模[1] 肖生平[1] 

机构地区：[1]广东省中山市博爱医院儿科,广东中山528403

出　　处：《实用临床医药杂志》2014年第15期181-184,共4页Journal of Clinical Medicine in Practice

摘　　要：目的观察和分析升白细胞治疗方案对急疹并发粒细胞缺乏症患儿的治疗效果。方法选取60例急疹合并粒细胞缺乏症患儿作为研究对象,将其随机分为观察组和对照组,每组30例。对照组患儿给予常规对症治疗,观察组患儿在对照组疗法的基础上给予粒细胞集落刺激因子(G-CSF)皮下注射治疗。在病程的第2、4、6、8、14天对2组患儿外周血标本的血细胞分类和计数情况进行检测和比较。结果 2组患儿在各观察时点出现白细胞减少症和中性粒细胞缺乏症的比例的差异无统计学意义(P>0.05),2组患儿在病程第2、4、8、14天出现中性粒细胞减少症的比例的差异无统计学意义(P>0.05),而在病程第6天,观察组患儿出现中性粒细胞减少症的比例显著低于对照组(P<0.05);2组患儿的外周血白细胞计数和中性粒细胞计数均于病程第4天显著下降(P<0.05),并于病程第6天开始上升且均显著高于病程第2天或第4天水平(P<0.05),在病程第14天时均恢复至正常水平,而且在病程第6、8天,观察组患儿外周血的白细胞计数和中性粒细胞计数均显著高于对照组(P<0.05)。结论应用G-CSF升白细胞治疗方案可显著提升急疹患儿外周血中白细胞和中性粒细胞水平,降低患儿并发中性粒细胞减少症的概率,有利于患儿安全、平稳地度过病程的关键时期。Objective To observe and analyze the curative effect of the leukocyte elevating therapy on treatment of subitum children with agranuiocytosis. Methods 60 subitum children with agranulocytosis were randomly divided into the observation group and the control group, 30 cases in each group. The control group was treated with the conventional treatments, while the observation group was treated with granulocyte colony stimulating factor （CJ-CSF） subcutaneous injection on the basis of the control group. At 2nd day, 4th day, 6th day, 8th day, 14th day of the duration, the classification and the counting of the peripheral blood samples of the children in the two groups were detected and compared. Results The proportion of the children with aplastic anemia in the observation group at 6tb day was significantly lower than that of the control group （P 〈 0.05）. The leukocyte and neutrophil countings in the peripheral blood of the children in the two groups at 4th day of the duration decreased significantly （P〈0.05）, the level at 6th day was significantly higher than those at 2nd day or 4th day （ P 〈 0.05 ）. The levels restored to normal levels at 14th day of the duration. At 6th day or 8th day of the duration, the leukocyte and neutrophil countings in the peripheral blood of the children in the observation group were significantly higher than those of the control group （P 〈 0.05）. Conclusion Application of G- CSF in elevation of the leukocyte can significantly improve the leukocyte and neutrophil levels in the peripheral blood of the patients with subitum, reduce the probability of aplastic anemia in the children, and help the children pass through the key course safely and smoothly.

关 键 词：幼儿急疹 粒细胞缺乏症 粒细胞集落刺激因子 

分 类 号：R557[医药卫生—血液循环系统疾病]