厄贝沙坦/氢氯噻嗪复方片对老年原发性高血压治疗效果  

Efficacy of irbesartan-hydrochlorothiazide tablet in treating essential hypertension in the elderly

作　　者：张明淋[1] 蔡靖[1] 王屹[1] 滕家良[1] 

机构地区：[1]江苏省省级机关医院药剂科,210024

出　　处：《江苏医药》2014年第14期1692-1694,共3页Jiangsu Medical Journal

摘　　要：目的评价厄贝沙坦/氢氯噻嗪复方片治疗老年原发性高血压(EH)的临床疗效。方法127例老年EH患者随机分为两组。观察组65例,口服厄沙贝坦/氢氯噻嗪复方片;对照组62例,口服氯沙坦钾/氢氯噻嗪复方片。均为每天1片,疗程8周。比较两组治疗前后血压、心率、肝肾功能、血糖、血脂和血钾变化。结果两组患者治疗后血压均下降(P<0.05)。观察组治疗8周总有效率高于4周(92.3%vs.84.6%)(P<0.05);对照组治疗4周和8周后总有效率相仿(75.8%vs.80.6%)(P>0.05)。治疗8周后,观察组总有效率高于对照组(P<0.05)。未观察到严重不良反应。结论厄贝沙坦/氢氯噻嗪治疗老年EH的疗效优于氯沙坦钾/氢氯噻嗪。Objective To evaluate the antihypertensive efficacy of irbesartan- hydrochlorothiazide（IH） tablet in the elderly with essential hypertension（EH）. Methods A total of 127 elder EH patients was treated with IH tablet （group A, 65 cases） and losartan potassium- hydrochlorothiazide（LPH） tablet（group B, 62 cases） in a dose of I tablet daily for 8 weeks. Blood pressure, heart rate, liver and kidney functions, blood glucose, blood lipids and serum potassium were detected and compared between two groups. Results The blood pressure in two groups was significantly decreased after treatment compared to before（P〈0. 05）. The total effectiveness rate in group A was higher in the 8 weeks of treatment than that in the 4 weeks （92. 3% vs. 84. 6%） （P〈0. 05） ,which was similar in group B（75.8% vs. 80.6%）（P〈0. 05）. The total effectiveness rate in the 8 weeks of treatment was higher in group A than that in group B（P〈0.05）. No severe adverse reactions were observed in both groups. Conclusion IH tablet is better than LPH tablet in the treatment of EH in the elderly.

关 键 词：厄贝沙坦 氯沙坦钾 氢氯噻嗪 原发性高血压 老年 

分 类 号：R541[医药卫生—心血管疾病]