退行性心瓣膜病患者心功能分级与脂联素、脑钠肽、超敏C反应蛋白的关系  

Relationship between adiponectin,B-type natriuretic peptide,high sensitivity C-reactive protein and cardiac function classification in patients with degenerative heart valvular disease

作　　者：周华兰[1] 胡有东[1] 郭殿选[1] 李侠[1] 徐培敬[1] 

机构地区：[1]徐州医学院附属淮安医院老年科,江苏淮安223002

出　　处：《实用临床医药杂志》2014年第16期25-27,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨退行性心瓣膜病(DHVD)患者不同心功能分级时,脂联素(APN)、脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)水平变化及其临床意义。方法按NYHA心功能分级将132例DHVD患者分为4组:心功能Ⅰ级组(A组)、心功能Ⅱ级组(B组)、心功能Ⅲ级组(C组)、心功能Ⅳ级组(D组)。检测所有患者血清APN、BNP、hs-CRP水平及左心室射血分数(LVEF),比较各组之间的差异。结果 DHVD患者血清APN、BNP、hs-CRP水平随着心功能恶化而逐渐升高,每组间差异均有显著统计学意义(P<0.01)。APN、BNP、hs-CRP水平与LVEF呈负相关(r=-0.36,P<0.01;r=-0.42,P<0.01;r=-0.39,P<0.01)。结论 APN、BNP、hs-CRP有助于DHVD患者心功能危险分层评价。Objective To evaluate the serum levels of adiponectin（APN）,B-type natriuretic peptide（BNP）,high sensitivity C-reactive protein（hs-CRP） and their clinical significance in patients with degenerative heart vascular disease（DHVD） according to different cardiac function classification. Methods According to New York Heart Association（NYHA）,132 patients with DHVD were divided into NYHA class Ⅰ group（A group）,NYHA class Ⅱ group（B group）,NYHA classⅢ group（C group）,NYHA class Ⅳ group（D group）. The serum levels of APN,BNP,hs-CRP were measured,left ventricular ejection fraction（LVEF） were determined by Doppler spectrum analysis. Results The serum levels of APN,BNP and hs-CRP levels significantly increased in patients with a higher class of NYHA（P〈0. 01）. The serum APN, BNP and hs-CRP levels were negatively correlated with LVEF in all patients（r =-0. 3 6,P 0. 0 1; r =-0. 42,P〈0. 01; r =-0. 39,P〈0. 01）. Conclusion The serum APN,BNP and hs-CRP levels are helpful in evaluating the changes in cardiac function of DHVD.

关 键 词：退行性心瓣膜病 脂联素 脑钠肽 超敏C反应蛋白 

分 类 号：R542.5[医药卫生—心血管疾病]