胰岛素生长因子-1及胰岛素因子结合蛋白-3在特发性矮小症诊断中的价值  

Value of IGF-1 and IGFBP-3 in diagnosis of children with idiopathic short stature

作　　者：黄丽娟[1] 羊柳[1] 徐星洋[1] 陈静秋[1] 陶岚[1] 

机构地区：[1]江苏省靖江市人民医院检验科,江苏靖江214500

出　　处：《实用临床医药杂志》2014年第16期186-187,190,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨血清中胰岛素生长因子-1(IGF-1)和胰岛素结合蛋白-3(IGFBP-3)在特发性身体矮小(ISS)诊断中的价值。方法 36例ISS儿童及50例正常对照儿童,分为青春前期组及青春期组,用化学发光法测定血清IGF-1和IGFBP-3水平。结果 ISS组与对照组IGF-1和IGFBP-3水平与年龄均存在显著正相关(r=0.435、r=0.718、P<0.01),青春期组血清IGF-1和IGFBP-3水平均高于相应的青春前期组。ISS儿童血清IGF-1水平、IGFBP-3水平均显著低于对照组(P<0.01)。结论血清IGF-1及IGFBP-3水平检测对ISS儿童临床诊断、生长监测及GH治疗随诊有着重要的临床价值。Objective To explore the value of serum insulin-like growth factor-1（IGF-1）and insulin-like growth factor binding protein-3（IGFBP-3） in diagnosis of children with idiopathic short stature（ISS）. Methods 36 ISS and 50 normal children were collected and divided into preadolescent group and adolescent group respectively. Serum IGF-1 and IGFBP-3 were detected by chemiluminescence analysis. Results There were significant positive correlations between age and the serum levels of IGF-1 and IGFBP-3（r = 0. 435,r = 0. 718,P〈0. 01） in both groups. The concentrations of IGF-1 and IGFBP-3 in adolescent group were significantly higher than those in preadolescent group,and the concentrations of IGF-1 and IGFBP-3 in ISS group were significantly lower than those in the control group（P〈0. 01）. Conclusion The detections of IGF-I and IGFBP-3 have a great value in the diagnose,growth monitoring and the treatment with GH for children with ISS.

关 键 词：特发性身体矮小 胰岛素生长因子-1 胰岛素结合蛋白-3 青春期 青春前期 

分 类 号：R681.1[医药卫生—骨科学]