5-氟尿嘧啶联合亚叶酸钙与奥沙利铂化疗方案治疗晚期结直肠癌的临床研究  

Clinical study of 5-FU/LV and L-OHP chemotherapy regimen for advanced colorectal cancer

作　　者：韩江琼[1,2] 陈云兰[3] 秦锴[4] 牛义淳 

机构地区：[1]昆明医科大学第三附属医院 [2]云南省肿瘤医院中西医结合科,昆明650118 [3]昆明医科大学第三附属医院干疗科,昆明650118 [4]都江堰市人民医院普外科,四川都江堰611830 [5]昆明医科大学第二附属医院消化科,昆明650101

出　　处：《中国临床药理学杂志》2014年第8期674-675,678,共3页The Chinese Journal of Clinical Pharmacology

基　　金：成都市卫生局科学研究基金资助项目(2011136)

摘　　要：目的：评价5-氟尿嘧啶联合亚叶酸钙（5-FU/LV）对比5-氟尿嘧啶联合亚叶酸钙与奥沙利铂（ FOLFOX4）化疗方案治疗晚期结直肠癌患者的临床疗效及安全性。方法对我院治疗的99例晚期结直肠癌患者进行回顾性分析，其中45例患者接受了5-FU/LV化疗方案，54例接受了FOLFOX4方案，比较2组患者临床疗效及化疗不良反应。结果 FOLFOX4组客观缓解率（ ORR ）为50.0％，显著高于5-FU/LV组（28.9％）（ P＜0.05）。5-FU/LV与FOLFOX4方案不良反应主要为粒细胞减少和胃肠道不良反应，2组患者Ⅲ～Ⅳ不良反应发生率差异无统计学意义（ P＞0.05）。结论 FOLFOX4方案治疗晚期结直肠癌客观缓解率较高，且不良反应发生率与5-FU/LV方案无明显差异。Objective To evaluate the efficacy and safety of two adju-vant chemotherapy regimens of 5-FU/LV and FOLFOX4 in patients with advanced colorectal cancer.Methods Ninety-nine patients with ad-vanced colorectal cancer were analyzed retrospectively.Of the 99 includ-ed patients , 45 were given the regimen of 5 FU/LV chemotherapy and other 54 subjects were given FOLFOX4 chemotherapy regimen.The clini-cal efficacy and adverse drug reactions in two groups were recorded and compared.Results The objective response rate （ ORR ） of FOLFOX4 group （ 50.0%） was much higher than 5 -FU/LV group （ 28.9%）.The main adverse drug reactions were granulopenia and gastrointestinal reactions in the two groups , but there was no significant statistical differ-ence （ P〉0.05 ）.Conclusion Compared with advanced 5 -FU/LV chemotherapy regimen , FOLFOX4 therapy is more effective for patients with colorectal cancer , with similar incidence of adverse drug reactions.

关 键 词：结直肠癌 化疗方案 临床研究 5-氟尿嘧啶 

分 类 号：R969.2[医药卫生—药理学] R735.3[医药卫生—药学]