四逆散冻干粉及其拆方镇静催眠作用的等效性研究  

Bioequivalence study on the effect of freeze-dry powder of Si-Ni-San on sleep time

作　　者：李越峰[1] 李廷利[2] 严兴科[1] 

机构地区：[1]甘肃中医学院药学院,兰州730000 [2]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《中国临床药理学杂志》2014年第8期719-720,共2页The Chinese Journal of Clinical Pharmacology

基　　金：教育部科学技术研究基金资助项目(212186);甘肃省财政厅高校基本科研业务费专项基金资助项目(2013-2);国家自然科学基金资助项目(81073077);2010年度甘肃省自然科学基金资助项目(1010RJZA212);2010甘肃中医学院引进人才科研启动基金资助项目(2010-3);2014年度甘肃省自然科学基金资助项目(145RJZA076)

摘　　要：目的研究四逆散冻干粉及其拆方对睡眠影响的等效性研究。方法用四逆散冻干粉与其拆方对阈剂量戊巴比妥钠致小鼠睡眠时间影响,研究其对睡眠的影响。结果四逆散冻干粉与其拆方可明显延长戊巴比妥钠所致小鼠睡眠时间,与空白组比较,差异有统计学意义(P<0.01)。四逆散整方组明显优于其拆方组(P>0.01)。结论四逆散冻干粉与其拆方在延长阈剂量戊巴比妥钠所致小鼠睡眠时间上确实有效,且实验重现性较好。Objective To study on the effects of freeze -dry powder of Si-Ni-San and its recipes on sleep time.Methods Freeze-dry pow-der of Si-Ni-San and its recipes were adopted to prolong the sleep time of mice induced by pentobarbital sodium , and then its effects on sleeping were investigated.Results Freeze-dry powder of Si -Ni -San and its recipes significantly prolonged the sleep time of mice induced by pentobarbi-tal sodium, and there was statistical difference when compared with blank group （P〈0.01）.The efficacy of freeze-dry powder of Si-Ni-San was better than its recipes.Conclusion Freeze-dry powder of Si -Ni -San and its recipes are effective to prolong the sleep time of mice induced by pentobarbital sodium , and the trial is reliable with good reproducibility.

关 键 词：四逆散冻干粉 拆方 戊巴比妥 

分 类 号：R338.63[医药卫生—人体生理学] R285.6[医药卫生—基础医学]