固有免疫细胞及其模式识别受体与表观遗传学调控研究进展  

Research progress in regulation of innate immune cells and pattern recognition receptors by epigenetics

作　　者：刘昕訸[1] 张彦洁[1] 罗茂财 任建敏[1] 吴菁[1] 杨克[1] 许春娣[1] 周同[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院,上海200025

出　　处：《生命科学》2014年第8期846-851,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81070567;81000163;81170363;81270801)

摘　　要：固有免疫细胞是机体抵御病原微生物的首道防线,亦是机体有效启动和维持免疫反应的重要参与者,而模式识别受体是固有免疫细胞发挥免疫功能的重要免疫分子,因此,机体对固有免疫细胞及其模式识别受体的精细调控尤为重要。表观遗传学是近年研究热点,其在固有免疫调节中的作用逐渐受到重视。就近年表观遗传学中的DNA甲基化、组蛋白共价修饰及非编码RNA等在调节固有免疫细胞分化发育及其模式识别受体的相关研究作一简述,以期为感染、炎症、自身免疫病等研究与防治提供新的思路和策略。Innate immune cells are the first line of defense against pathogens, as well as the participants that activate and maintain the immune responses, while pattern recognition receptors （PRRs） are the vital immune molecules mediating immune function. Therefore, the regulation of innate immune ceils and PRRs is important for the body. Recent years, epigenetics has been one of the hot spots, the role of which in modulating innate immune is getting more and more attentions. In this review, we summarize DNA methylation, histone modification, and non-coding RNAs in regulating innate immune cell differentiation, development and PRRs, to provide new thoughts and approaches for prevention and treatment of infectious, inflammatory and autoimmune diseases.

关 键 词：固有免疫细胞 模式识别受体 表观遗传学 调控机制 

分 类 号：Q344[生物学—遗传学] R392[医药卫生—免疫学]