1,2-苯并异噻唑啉-3-酮-2-甲酸苯酯类化合物的合成及防污性能研究  

Synthesis and Antifouling Properties of 3-Oxobenzo[d] Isothiazole-2(3H)-Phenyl Formic Esters

作　　者：魏婕 王旭裕 陈华勇 王向辉[2] 林强[2] 王爱民 杨建新[1] 

机构地区：[1]海南大学热带生物资源教育部重点实验室,海南省精细化工工程技术研究中心,海南大学材料与化工学院,海南海口570228 [2]海南师范大学化学与化工学院,海南海口571158

出　　处：《涂料工业》2014年第9期15-19,共5页Paint & Coatings Industry

基　　金：国家自然科学基金(20962007)苯并异噻唑啉酮类绿色海洋防污剂的合成及生物活性研究资助项目

摘　　要：通过取代苯酚与苯并异噻唑啉酮(BIT)反应,合成了6个未见文献报道的1,2-苯并异噻唑啉-3-酮-2-甲酸苯酯类化合物作为一类新型防污剂,研究了合成化合物对藤壶二期无节幼虫的急性毒性效应。实验结果表明该类化合物对藤壶幼虫均有良好的毒杀作用;活性最优者,24 h半数致死浓度仅为0.47 mg/L。浅海挂板90 d防污效果良好,未见明显污损生物附着。引入具有杀菌活性的酚类基团后,1,2-苯并异噻唑啉-3-酮-2-甲酸苯酯类化合物比BIT具有更优良的防污性能。Six novel compounds （ i.e., 3-oxobenzo [ d ] isothiazole-2 （ 3 H ） -phenyl formicesters） were synthesized from benzo-isothiazolone and substituted phenol as a kind of novelantifouling agent. The structures of the compound were characterized by means of FT-IR and HNMR. The acute toxicity effects of benzo-isothiazolone derivatives on the barnacle larvaewere investigated. The results showed that all of the compounds exhibited prominent toxiceffect. The best half lethal concentration of compound was only 0. 47 mg/ L. The shallow seaexperiments showed that the antifouling effect was excellent. The test panels could not be atta-ched by marine fouling organisms in the seawater for 90 days. The antifouling effect of com-pounds incorporated with the phenol groups was better than BIT.

关 键 词：苯并异噻唑啉酮 藤壶 毒性 浅海挂板 

分 类 号：TQ630.4[化学工程—精细化工]