注射用盐酸头孢甲肟在输液中的降解动力学  

Kinetics of degradation of cefmenoxime hydrochloride for injection in infusion solutions

作　　者：王建欣[1] 杨继章[1] 张振杰[1] 靳晓园[2] 

机构地区：[1]河北医科大学第一医院,河北石家庄050031 [2]河北医科大学第二医院,河北石家庄050000

出　　处：《中国医院药学杂志》2014年第16期1342-1346,共5页Chinese Journal of Hospital Pharmacy

基　　金：河北省医学科学研究重点课题(编号:20120276)

摘　　要：目的:研究注射用盐酸头孢甲肟在氯化钠注射液和5%葡萄糖注射液中的降解动力学。方法:采用高效液相色谱法测定头孢甲肟在不同pH值、不同温度、不同离子强度的大输液中的降解动力学参数。结果:2个不同厂家不同规格的头孢甲肟在2种大输液中的降解动力学过程符合一级动力学特征,其最稳定pH值约为6.5,随着温度和离子强度增加,其降解速率加快。结论:头孢甲肟的降解速率与溶液pH值、温度、离子强度有关;pH值和温度对头孢甲肟的降解作用较为明显。OBJECTIVE To investigate the kinetic characteristics of degradation of cefmenoxime hydrochloride for injection in sodium chloride injection and 5% glucose injection. METHODS A HPLC method was established to measure the kinetic parameters of degradation of cefmenoxime in infusion solutions with various pH values, temperatures and ionic strengths. RESULTS It was found that the kinetics of degradation of cefmenoxime from two manufacturers corresponded with the firstorder kinetics, and the prim for cefmenoxime was about 6. 5. The degradation rate increased with temperature and ionic strength. CONCLUSION Degradation rate of cefmenoxime is related with pH, temperature and ionic strength, especially pH value and temperature.

关 键 词：头孢甲肟 降解动力学 高效液相色谱法 氯化钠注射液 5%葡萄糖注射液 稳定性 

分 类 号：R969[医药卫生—药理学]