社区健康老年人的弗明汉评分与认知功能的关系研究  

Relationship Between Framingham Risk Score for Coronary Artery Disease and Cognitive Function in Healthy Community Elders

作　　者：王微[1] 侯宇[1] 田志鹏[1] 刘丽楠 周雪莹[1] 

机构地区：[1]沈阳医学院附属中心医院循环内科,辽宁省沈阳市110024

出　　处：《中国循环杂志》2014年第8期620-623,共4页Chinese Circulation Journal

摘　　要：目的：探究社区老年人弗明汉评分与认知功能的相关性。 方法：利用弗明汉评分方程评价276名健康老年人发生冠心病的风险值。根据弗明汉评分值将研究对象分为高危组（10年内发生冠心病风险＞20%），中危组（10年内发生冠心病风险10%~20%），低危组（10年内发生冠心病风险＜10%）。用简易精神状态量表（MMSE）与中国成人智力量表（CISA）评估认知能力，比较不同危险分组间的认知功能水平差异。 结果：随着发生冠心病的风险的递增（即低危组、中危组、高危组），研究对象的MMSE得分下降[（26.9±1.45）分vs（24.3±1.53）分vs（22.2±1.43）分，P=0.014]；Pearson相关分析的结果显示，研究对象的MMSE得分与弗明汉评分值呈负相关关系（r=-0.213，P〈0.001），弗明汉评分得分对研究对象认知功能有显著相关关系的项目包括：MMSE得分、问题解答、宫格补缺、口头运算、词义分辨、分类概括（r=-0.247，-0.167，-0.132，-0.152，-0.256，P均〈0.05）。 结论：健康老年人发生冠心病的风险水平与认知功能存在负相关，弗明汉评分危险积分值越高，认知水平越低。Objective： To study the relationship between Framingham risk score for coronary artery disease （CAD） and cognitive function in healthy community elders. Methods： A total of 276 healthy community elders were evaluated by Framingham score to predict the risk for suffering from CAD in 10 years. The subjects were divided into 3 groups. High risk group （the risk 〉 20%）, n=46, Mid risk group （the risk at 10%-20%）, n=76 and Low risk group （the risk 〈 10%）, n=154. The cognitive function was measured by mini-mental state examination （MMSE） and China adult intelligence scale （CISA）. The differences of cognitive function levels to 3 CAD risk groups were studied. Results： With the increased CAD incidence from Low risk, Mid risk to High risk groups, the MMSE score reduced accordingly （26.9 ± 1.45） vs （24.3 ± 1.53） vs （22.2 ± 1.43）, P=0.014. Pearson analysis presented that MMSE score was negatively related to Framingham risk score （r=-0.213, P〈0.001）. There were several elements of cognitive function related to Framingham risk score including MMSE score, question answering, grid filling, oral arithmetic and word distinguishing （r=-0.247）, （r=-0.167）, （r=-0.132）, （r=-0.152） and （r-0.256）, all P〈0.05. Conclusion： CAD risk level was negatively related to cognitive function, the higher Framingham risk score resulted in the lower cognitive function in healthy community elder subjects.

关 键 词：冠心病 认知功能 老年人 危险因素 弗明汉评分 

分 类 号：R541[医药卫生—心血管疾病]