超声心动图评价低温条件下兔左室局部心功能的变化  被引量:2

Changes of regional left ventricular function of rabbit in hypothermia by echocardiography

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作  者:张筠[1] 于馨[1] 曹军英[1] 黄昕 

机构地区:[1]沈阳军区总医院特诊科,辽宁沈阳110840 [2]沈阳军区政治部第二干休所,辽宁沈阳110032

出  处:《临床军医杂志》2014年第8期771-773,共3页Clinical Journal of Medical Officers

基  金:全军"十一.五"课题科技攻关项目(08G001);辽宁省2009年自然科学基金(20092091)

摘  要:目的探讨低温对兔心脏收缩及舒张功能的影响。方法将24只新西兰大白兔随机分为常温组和低温组,每组12只。分别置于室温(22~25℃)以及低温(-15^-18℃)条件下。应用常规超声比较两组射血分数(EF)、心率(HR)、舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、短轴缩短率(FS)。应用组织多普勒超声技术(TDI)检测兔心尖四腔心切面二尖瓣环的收缩期和舒张早期峰值运动速度和应变率。结果常规超声心动图显示,低温组HR明显低于常温组(P<0.01),但两组EDV、ESV、SV、EF及FS比较差异无统计学意义(P>0.05)。低温组室间隔侧二尖瓣环舒张早期运动速度(Em)及二尖瓣环两侧舒张早期的峰值应变率(SRe)均明显低于正常组(P<0.05)。低温组二尖瓣环收缩期运动速度(Sm)及收缩期峰值应变率(SRs)也低于正常组,但差异无统计学意义(P>0.05)。结论低温条件可引起兔心功能的减低,并以舒张功能减低为主。超声心动图可以早期发现低温对兔局部心功能的影响。Objective To elucidate whether hypothermia induce dysfunction of myocardial contractility and relaxation in rabbits by echocardiography. Methods Twenty-four New Zealand rabbits were randomly divided into two groups (n = 12/group ). Control group was treated indoor at the temperature of 22- 25 degrees Celsius, and trial (hypothermia) group outside at the temperature of -15 through -18 degrees Celsius. Results The trial group exhibited a significantly lower level of heart rate (HR) than the control group (P 〈 0.01 ). There were no significant differences in end-diastole volume(EDV) , end-systolic volume(ESV) , stroke volume (SV) , ejection fraction (EF) and fractional shortening (FS) between the two groups (P 〉 0.05 ). Early diastolic velocity of mitral annulus (Em) in 'interventricular septum and early diastolic strain rate (SRe) of mitral annulus were significantly lower in the trial group than in the control ( P 〈 0.05 ). Systolic velocity of mitral annulus (Sm) , systolic strain rate ( SRs ) and SRe in left ventricle decreased slightly in the trial group ( P 〉 0.05 ). Conclusion Hypothermia decreased both systolic and diastolic function of left ventricle, especially in diastole. Ecohcardiography may be used to find early myocardial dysfunction induced by hypothermia.

关 键 词:低温 超声心动图 左心室功能 

分 类 号:R540.45[医药卫生—心血管疾病]

 

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