聚合物胶束在提高抗肿瘤疗效中的研究进展  

Polymeric Micelles for Enhancing Antitumor Effect

作　　者：邱丽筠[1] 俞淑文[1] 于克炜[1] 

机构地区：[1]山东大学附属济南市中心医院药学部,山东济南250013

出　　处：《中国医药指南》2014年第23期72-75,共4页Guide of China Medicine

摘　　要：恶性肿瘤是严重威胁人类健康的一类疾病。功能化的聚合物胶束作为一种新型的纳米给药系统在口服、静脉注射给药治疗肿瘤中发挥着重要的作用。本文从口服给药以及静脉给药两个方向分别探讨了生物黏附胶束,主动靶向胶束,pH敏感胶束,温度敏感胶束以及逆转多药耐药胶束在提高抗肿瘤疗效中的重要作用以及最新研究进展。Malignant tumor is A kind of disease that seriously threated to human health. Functionalized polymeric micelles （PMs）, A promising new drug delivery system, has been playing an important role in the treatment of tumor both in oral admistration and intravenous administration. In this article, we focused our attention on bioadhesive PMs, active targeting PMs, pH-sensitive PMs, thermosensitive PMs and reverse multidrug resistance （MDR） PMs, discussing the important role and the latest research progress from the two aspects of oral and intravenous administration.

关 键 词：聚合物胶束 功能化修饰 抗肿瘤 口服给药 静脉给药 

分 类 号：R979.1[医药卫生—药品]