简单铁盐催化的Suzuki-Miyaura偶联反应研究  

Simple Iron Salts Catalyzed Suzuki-Miyaura Coupling Reactions

作　　者：刘岩[1] 谷宁宁[1] 刘亚帅 刘平[1] 马晓伟[1] 谢建伟[1] 代斌[1] 

机构地区：[1]石河子大学化学化工学院/新疆兵团化工绿色过程重点实验室/省部共建国家重点实验室培育基地,石河子832003

出　　处：《石河子大学学报（自然科学版）》2014年第1期93-96,共4页Journal of Shihezi University(Natural Science)

基　　金：国家重点基础研究发展计划(973计划)项目(2012CB722603);国家自然科学基金项目(21103114);兵团博士基金项目(2012BB010);石河子大学优秀青年科技人才培育计划项目(2012ZRKXYQ-YD02)

摘　　要：开发一种廉价、无毒的过渡金属用于催化Suzuki-Miyaura偶联反应具有重要的现实意义。本文选取简单的铁盐作为研究对象,考察了不同铁盐、碱以及溶剂对催化Suzuki-Miyaura偶联反应的影响。结果表明：在乙醇溶液中,K2CO3作为碱,5 mol%FeCl2·4H2O在80℃下能够有效催化各种溴代芳烃及碘代芳烃与芳基硼酸的Suzuki-Miyaura偶联反应,产率在33%~99%之间。Transition metal-catalyzed Suzuki-Miyaura coupling reaction is one of the most important methods for the formation of aryl C-C bond,so the development of cheap,intoxic transition metal-catalyzed Suzuki-Miyaura reaction is of much great value in academic and industrial application.In this paper,iron salts were tested as possible candidates to study their catalytic activity for the Suzuki-Miyaura reactions,we investigated the effects of iron salts,bases and solvent on the coupling reactions. The results showed that the reactions of aryl bromides,aryl iodides with arylboronic acids in toluene could be carried out smoothly by 5 mol % FeCl2·4H2O in the presence of K2CO3at 80 ℃ for 10 h,and 33%～99% yields are obtained.

关 键 词：铁 Suzuki-Miyaura反应 催化 液晶化合物 

分 类 号：O625.13[理学—有机化学] TQ423.116[理学—化学]