2型糖尿病周围神经病变患者血清胱抑素C水平及其临床意义  

A change of serum cystatin C in diabetic peripheral neuropathy in type 2 diabetic patients and its clinical significance

作　　者：陈兰英[1,2] 郑芬萍[1] 李红[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院内分泌科,杭州310016 [2]杭州市余杭区第五人民医院内分泌科

出　　处：《中国糖尿病杂志》2014年第8期700-703,共4页Chinese Journal of Diabetes

基　　金：国家科技支撑计划(2012BAI02B03);浙江省重大科技专项重点社会发展项目(2009C0310-4)

摘　　要：目的探讨糖尿病周围神经病变(DPN)患者血清胱抑素C(Cys-C)水平及其临床意义。方法选取T2DM患者219例,其中T2DM未合并周围神经病变者(T2DM组)117例,T2DM合并周围神经病变者(DPN组)102例,另选健康对照者(NC组)47名,检测各组血清Cys-C水平。结果 DPN组血清Cys-C水平高于NC、T2DM组(P<0.05),T2DM组与NC组比较差异无统计学意义。在肾小球滤过率相似的情况下,随着血清Cys-C水平升高,正中神经潜伏期呈逐渐延长趋势,运动传导波幅和腓肠神经的感觉神经传导速度(SCV)呈逐渐下降趋势。Logistic多元逐步回归分析显示,病程长,FPG、HbA1c和血清Cys-C水平升高,均可能增加T2DM患者DPN风险。结论血清Cys-C水平与DPN发生关系密切。Objective To investigate the correlation between serum cystatin-C （Cys-C） level and diabetic peripheral neuropathy （DPN） in T2DM patients.Methods 219 T2DM patients were selected,divided into two groups：T2DM patients without DPN （T2DM group,n=117） and with DPN （DPN group,n=102）,and 47 healthy subjects as controls （NC group）.Serum Cys-C level was measured by microparticle enhanced turbidimetry.Results The serum Cys-C level was higher in DPN group than in NC and T2DM group （P＜0.05）.However,there was no difference in serum Cys-C levels between T2DM and NC group.In the condition of similar glomerular filtration rate,along with the gradual increase of serum Cys-C level,the median nerve latency increased,sural nerve motor conduction and amplitude of SCV decreased gradually.Multivariate logistic regression analysis revealed that the prolonged disease course,elevated serum Cys-C levels,higher HbA1 c and elevated FPG were the risk factors for DPN in T2DM patients.Conclusion The serum level of Cys-C is related to the occurrence of DPN in T2DM.

关 键 词：血清胱抑素C 糖尿病 2型 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]