亚冬眠疗法延长狂犬病患者生存时间  

Sub hibernation therapy to prolong the survival time of patients with rabies

作　　者：向江琳[1] 谢婷[1] 刘晞照[1] 陈永宏[1] 杨兴春[1] 郭灿[1] 郭晓华[1] 

机构地区：[1]重庆三峡中心医院感染科,重庆404100

出　　处：《中国现代医学杂志》2014年第21期87-89,共3页China Journal of Modern Medicine

摘　　要：目的观察亚冬眠疗法改善狂犬病的临床症状和遵医行为的效果。方法42例兴奋期的狂犬病患者随机分为治疗组和对照组。对照组患者给予安定等镇静剂治疗；治疗组选用等量的氯丙嗪和异丙嗪混合，按每0．5～1．0mg／kg·次给药，观察2组患者的治疗有效率、症状、体征消失时间及生存时间的改善程度。结果治疗组的治疗总有效率明显高于对照组（P〈0．05）；治疗组发热、恐惧感、恐水、恐风、发作性咽肌痉挛等主要症状及体征消失时间短于对照组（P〈0．05）；治疗组平均生存时间为6．8d，对照组为4．2d，差异具有显著性，P〈0．05。但两组均无治愈病例。结论亚冬眠疗法时改善狂犬病恐水、恐风、发作性咽肌痉挛等症状，提高病人接受氧疗、输液治疗等遵医行为，延长生存时间起到积极的作用。[ Objective ] To apply subhibernation therapy in patients with rabies,and observe the effectiveness of reducing the rabies patient＂ symptom and improve the patients＂ obey-doctor action. [Methods] 42 cases of The ra- bies patient who were in excitement stage were randomly divided into experimental and control groups. The former used equivalence dose of chlorpromazine and promethazine 0.5-1 mg/kg toties quoties, while the latter adopted traditional medical method such as diazepam. Observed the difference in two group with treatment effectiveness, the disappearance time of symptom and sign, the survival time of patients. [ Results ] Experimental group patients had a better result compared with control group （P 〈0.05）, such as treatment effectiveness is higher, the disappearance time of main symptom and sign is shorter （P 〈0.05 ）, the survival time of patients in experimental group is 6.8 days while in control group is 4.2 days （P 〈0.05）. [ Conclusions ] Application of subbibemation therapy in rabies can play active roles in reducing the rabies patient＂ symptom, improving the patients＇obey-doctor action such as receive oxygen therapy and transfusion, prolongation the survival time of patients.

关 键 词：亚冬眠疗法 狂犬病 应用 

分 类 号：S855.3[农业科学—临床兽医学]