血小板在活血化瘀中药研究中的应用  

Applications of platelets in studies on traditional Chinese medicines promoting blood circulation to remove blood stasis

作　　者：王凤琴[1] 陈岑[1] 夏之宁[1] 杨丰庆[1] 

机构地区：[1]重庆大学化学化工学院,重庆400030

出　　处：《中国中药杂志》2014年第16期2993-3003,共11页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81202886;21275169)

摘　　要：不同形式的血栓性疾病严重威胁人类的健康,阿司匹林、氯吡格雷等抗血小板聚集类药物是临床上常用的治疗用药。但随着西药抗血小板聚集药物抵抗性及副作用的出现,传统活血化瘀中药的抗血小板聚集研究逐渐成为一个重要方向。血小板是血栓形成的主要参与者之一,作为生物活性材料在活血化瘀中药研究中扮演着重要角色,主要包括中药抗血小板聚集活性评价及其活性成分筛选2个方面。该文针对近年来血小板在活血化瘀中药研究方面的应用进行了综述,为进一步的研究提供参考。Thrombotic diseases in different forms become a great threat to human health. Such anti-platelet aggregation drugs as aspirin and clopidogrel are common drugs in clinic. However,along with the appearance of resistance and side effects of western anti-platelet aggregation drugs,anti-platelet aggregation traditional Chinese medicines promoting blood circulation to remove blood stasis have gradually become an important study orientation. Platelet is one of major participant in thrombosis,and plays an important role as a bioactive material in studies on traditional Chinese medicines promoting blood circulation to remove blood stasis,mainly involving two aspects——the evaluation for the anti-platelet aggregation activity of traditional Chinese medicines and the screening of their active components. This paper summarized the applications of platelets in studies on traditional Chinese medicines promoting blood circulation to remove blood stasis,so as to provide basis for further studies.

关 键 词：活血化瘀 血小板活化 抗血小板活性评价 活性成分筛选 

分 类 号：R285.5[医药卫生—中药学]