中华苦荬菜根部化学成分研究  

Chemical constituents from roots of Ixeris chinensis

作　　者：张树军[1] 王丹[1] 许策[1] 王金兰[1] 赵明[1] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006

出　　处：《中国中药杂志》2014年第16期3089-3093,共5页China Journal of Chinese Materia Medica

基　　金：黑龙江省自然科学基金项目(B201205)

摘　　要：采用硅胶柱色谱,HPLC等方法对中华苦荬菜根部化学成分进行分离纯化,得到15个化合物,依据理化性质和波谱数据分析鉴定它们的结构分别为chinensioide G(1),chinensioide B(2),10α-羟基-愈创木烷-12,6-内酯-3-酮(3),chinensioide C(4),10α-羟基-11βH-4(5)-愈创木烯-12,6-内酯(5),3β,10α-二羟基-4βH-11(13)-愈创木烯-12,6-内酯(6),3β,10α-二羟基-4βH,11βH-愈创木-12,6-内酯(7),3β,10α-二羟基-4(15),11(13)-愈创木二烯-12,6-内酯(8),咖啡酸(9),对羟基苯乙酸(10),对羟基苯乙酸甲酯(11),对羟基苯乙酸乙酯(12),β-谷甾醇(13),胡萝卜苷(14),ixerin D(15)。其中化合物1为新化合物,命名为chinensioide G,化合物6,7首次从该植物中分离得到。Silica gel column chromatography and preparative HPLC were applied to isolate the chemical constituents from the roots of Ixeris chinensis. Fifteen compounds were isolated and their structures were elucidated by the physicochemical properties and spectral analysis as chinensioide G（ 1）,chinensioide B（ 2）,10α-hydroxy-guaia-12,6-lactone-3-keton（ 3）,chinensioide C（ 4）,10α-hydroxy-11βH-guaia-4（ 5）-ene-12,6-lactone（ 5）,3β,10α-dihydroxy-11βH-guaia-11（ 13）-ene-12,6-lactone（ 6）,3β,10α-dihydroxy-4βH,11βH-guaia-12,6-lactone（ 7）,3β,10α-dihydroxy-guaia-4（ 15）,11（ 13）-diene-12,6-lactone（ 8）,caffeic acid（ 9）,p-hydorxyphenylacetic acid（ 10）,methyl p-hydroxyphenylacetate（ 11）,ethyl p-hydroxyphenylacetate（ 12）,sitosterol（ 13）,daucosterol（ 14）,and ixerin D（ 15）. Compound 1 was new,and 6 and 7 were isolated from I. chinensis for the first time.

关 键 词：中华苦荬菜 倍半萜 chinensioide G 

分 类 号：R284.1[医药卫生—中药学]