基于网络药理学探析复方阿胶浆辅助治疗肿瘤的作用机制研究  

Study on action mechanism of adjuvant therapeutic effect compound Ejiao slurry in treating cancers based on network pharmacology

作　　者：许海玉[1,2] 王松松[1] 杨洪军[1] 边宝林[1] 田守生 王东亮 卢朋[3] 周祥山 尤金花 黄璐琦[5] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]国家胶类中药工程技术研究中心,山东聊城252201 [3]中国科学院自动化研究所,北京100190 [4]山东东阿股份有限责任公司,山东聊城252201 [5]中国中医科学院中药资源中心,北京100700

出　　处：《中国中药杂志》2014年第16期3148-3151,共4页China Journal of Chinese Materia Medica

基　　金：国家科技支撑计划项目(2008BA151B03);国家自然科学基金项目(81202793)

摘　　要：近年来,复方阿胶浆在临床上常用于癌症患者的治疗,疗效十分确切,在该文中,首先,通过从中药化学成分数据库和文献收集,建立了复方阿胶浆的化学成分库,然后,采用MetaDrug软件对复方阿胶浆进行靶标预测,获得"成分-靶标"网络,再次,通过与肿瘤的靶标网络进行比对、分析,获得"成分-靶标-肿瘤靶标"异质网络,并通过进一步地基因功能分析和代谢通路分析。结果发现,复方阿胶浆既能直接调节癌症细胞分化、生长、增殖和凋亡,具有直接的抗肿瘤作用,同时通过补血、提高免疫力,对肿瘤具有辅助治疗作用。Recently,compound Ejiao slurry（ FFEJJ） had been applied to treat cancer patients in clinic,with obvious curative effect. In this study,data and literatures were collected from the TCM chemical component database to establish the chemical component database of FFEJJ. Afterwards,MetaDrug software was used to predict the targets of FFEJJ and obtain the compound-target network. Next,the compound-target network was compared and analyzed to obtain the ＂ compound-target-tumor target＂ heterogeneous network. Besides,further analysis was made on gene functions and metabolic pathway. The results indicated that FFEJJ could directly resist tumors by regulating cancer cell differentiation,growth,proliferation and apoptosis,and show an adjuvant therapeutic effect by enriching the blood and increasing the immunity.

关 键 词：复方阿胶浆 网络药理学 “成分-靶标”网络 肿瘤靶标网络 

分 类 号：R285.5[医药卫生—中药学]