壮骨止痛胶囊抗实验性绝经后骨质疏松作用的三维组学分析  

Tri-dimensional omics analysis on effect of Zhuanggu Zhitong capsule against experimental postmenopausal osteoporosis

作　　者：李劲平[1] 曾英[2] 雷晓明[2] 张国民[2] 刘慧萍[2] 莫新民[2] 

机构地区：[1]中南大学,湖南长沙410013 [2]湖南中医药大学,湖南长沙410208

出　　处：《中国中药杂志》2014年第16期3203-3207,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(30873291;81273816)

摘　　要：该文提出了多维组学新概念,指出多维组学是研究中药复方药效物质基础与机制研究的恰当方法。以壮骨止痛胶囊抗实验性绝经后骨质疏松作用为例,从中药化学组学、基因转录组学、蛋白质组学等三维组学角度,较系统地阐明了壮骨止痛胶囊防治绝经后骨质疏松的药效物质与作用机制,同时,创造性地设计了一个三维表格直观地展现三维组学研究结果。该研究为中药复方药效物质和作用机制研究提供了一种新的思考方式和解决方案。To propose the new concept of multidimensional omics,and define that the multidimensional omics is a proper method for studying the material base and mechanism of traditional Chinese medicine（ TCM） compounds. Zhuanggu Zhitong capsule was taken for example to study its effect against experimental postmenopausal osteoporosis. From the perspective of chemi-omics,genomics and proteomics of TCM,it systematically interpreted the efficacious materials and mechanisms of Zhuanggu Zhitong capsule in preventing and treating experimental postmenopausal osteoporosis,while taking the lead in designing a three dimensional form to intuitively exhibit the results of the multidimensional omics study. This study provides a new idea and solution for studies on the efficacious materials and mechanisms of TCM compounds.

关 键 词：多维组学 中药复方 物质基础 机制研究 壮骨止痛胶囊 

分 类 号：R285[医药卫生—中药学]