超高效液相色谱-串联质谱法同时测定聚合物食品包装材料中8种添加剂  

Simultaneous determination of eight additives in polymer food packaging materials by ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry

作　　者：张旭龙[1,3] 刘银 巩治国[3] 王鹏举 王吉德[1] 封顺[1] 

机构地区：[1]新疆大学化学化工学院,石油天然气精细化工教育部&自治区重点实验室,新疆乌鲁木齐830046 [2]库尔勒出入境检验检疫局,新疆库尔勒841000 [3]新疆出入境检验检疫局技术中心,新疆乌鲁木齐830063

出　　处：《色谱》2014年第8期827-831,共5页Chinese Journal of Chromatography

基　　金：国家自然科学基金项目(201147005);国家质检总局项目(2014IK073)

摘　　要：建立了同时测定聚合物食品包装材料中8种常用添加剂 Irgafos 168、Irganox 1010、Irganox 1076、丁基羟基茴香醚（BHA）、没食子酸丙酯（PG）、没食子酸十二酯（ DG）、叔丁基对苯二酚（ TBHQ）和苯三唑甲酚（ UV-326）的超高效液相色谱-串联质谱方法。试样以二氯甲烷为溶剂进行超声提取；采用 Waters BEH-C18柱（50 mm ±2.1 mm，1.7μm）分离，以0.05％甲酸水溶液和甲醇为流动相进行梯度洗脱；采用电喷雾离子源正、负离子切换模式和多反应监测模式进行检测。8种添加剂在相应的质量浓度范围内定量离子的峰面积与质量浓度均呈良好线性关系（相关系数 R2均大于0.993），回收率为63.9％～127.0％，相对标准偏差（RSD，n =6）≤15.8％，检出限（ S / N =3）为0.13～5.50μg / L，定量限（S / N =10）为0.45～17.50μg / L。该方法简便快捷、灵敏度高，适合食品包装材料中常用添加剂的分析测定。An ultra-high performance liquid chromatography-tandem mass spectrometry （UPLC-MS / MS）method was proposed for the simultaneous determination of eight additives （ Irgafos 168（tri（2. 4-di-tert-butylphenyl）phosphite）,Irganox 1076（octadecyl-β-（4-hydroxy-3, 5-di-tert-butyl- phenyl）propionate）,Irganox 1010（pentaerythritol tetrakys 3-（3,5-di-tert-butyl-4-hydroxyphenyl）propionate）,BHA（ butyl hydroxy anisole）,TBHQ（ tertiary butylhydroqui-none）,PG（ propyl gallate）,DG（ dodecyl gallate）,UV-326（ 2-（ 2′-hydroxyl-3′-tert-butyl-5′-methylphenyl）-5-chlorobenzotriazole ） in food packaging materials. After extracted by chlo-romethane through ultrasonic extraction,the samples were analyzed by UPLC-MS / MS. The chromatographic conditions were optimized,and the best separation was obtained on a Waters BEH-C18 column（50 mm±2. 1 mm,1. 7 μm）with gradient elution of 0. 05% acetic acid solu-tion and methanol. The analysis was performed by UPLC-MS / MS with electrospray ionization （ESI）source in switching between the positive and negative ion modes in one run for multiple reaction monitoring. The eight additives showed good linear relationships in the ranges with all the correlation coefficients（R 2 ）more than 0. 993. The limits of detection（LODs,S / N = 3）and limits of quantitation（LOQs,S / N = 10）of this method were 0. 13-5. 50 μg / L and 0. 45-17. 50μg / L,respectively. The recoveries were in the range of 63. 9% - 127. 0% with all the RSDs ≤15. 8% （n = 6）. This method is simple,accurate and effective for the analysis of the eight addi-tives in food packaging materials.

关 键 词：超高效液相色谱-串联质谱 添加剂 食品包装材料 聚合物 

分 类 号：O658[理学—分析化学]