Fosl2基因的研究进展  

Research Progress of Fosl2 Gene

作　　者：范兴兴[1] 李新建[1] 郭吉利[1] 李改英[1] 吕刚[1] 任广志[1] 

机构地区：[1]河南农业大学牧医工程学院,河南郑州450000

出　　处：《中国畜牧兽医》2014年第8期80-84,共5页China Animal Husbandry & Veterinary Medicine

基　　金：河南省重大科技专项资金资助(111100110300);河南省生猪产业技术体系创新团队(S2012-06)

摘　　要：Fosl2(Fos-like antigen 2)属于活化因子蛋白1(activator protein-1,AP1)转录因子家族中的一种,在多种组织中均有显著表达,对哺乳动物的生长发育、生殖性状、免疫应答等起到重要的作用。近年来,随着研究的深入,人们发现Fosl2基因与脂肪代谢、骨骼发育及疾病和癌症的发生有着重要联系。作者综述了Fosl2基因的结构与组织表达分布,同时概述了其在脂肪代谢、骨骼发育、癌症发生及眼部发育等重要生理过程中的作用,并对其生物功能进行了展望,以期为更深层次的研究和提高动物的生长发育性状提供参考。Fosl2 （Fos-like antigen 2） that is expressed in a wide range of tissues during animal development belongs to the activator protein-1 （AP1） transcription factor family that includes the various isoforms of Fos and Jun, which play diverse and important roles in animal growing development and immunologic response. Following the indepth research of recent years, people found that Fosl2 has a very close relationship with animal fat metabolism, skeleton development and cancer growth. This article reviewed the gene structure and the tissue distribution, also generalized the function of Fosl2 in animal fat metabolism, skeleton development, cancer growth and eye development. The prospects in study on the biological function were discussed in order to show a clearly direction for the deeper study and the animal growth traits promotion.

关 键 词：Fosl2基因 组织表达与结构 脂肪代谢 骨骼发育 生物学功能 

分 类 号：Q78[生物学—分子生物学]