硝苯地平缓释片联合吲达帕胺片对原发性高血压患者血压水平和肾功能的影响  

Influence of nifedipine extended release tablets combined with indapamide tablets on blood pressure and renal function of patients with primary hypertension

作　　者：朱路平[1] 肖飞 

机构地区：[1]河南省疾病预防控制中心门诊部药房,河南郑州450003 [2]河南省鹤壁市人民医院心内科,河南鹤壁458030

出　　处：《中国现代医生》2014年第24期28-30,共3页China Modern Doctor

摘　　要：目的分析硝苯地平缓释片联合吲达帕胺片对原发性高血压患者血压和肾功能的影响。方法随机将117例原发性高血压患者进行分组,对照组予硝苯地平缓释片,实验组予硝苯地平缓释片联合吲达帕胺片,3个月后观察综合疗效、血压水平变化、肾功能指标和药物不良反应。结果实验组总有效率91.53%高于对照组75.86%,差异有统计学意义(P<0.05);实验组对血压和肾功能影响幅度小于对照组(P<0.01);实验组不良反应发生率10.17%与对照组8.62%比较,差异无统计学意义(P>0.05)。结论硝苯地平缓释片联合吲达帕胺片降低原发性高血压的血压和控制血压水平效果确切,能够增加肾脏血流量以降低肾脏损害,安全可靠。Objective To analyze the influence of nifedipine extended release tablets combined with indapamide tablets on the blood pressure and renal function of patients with primary hypertension. Methods A total of 117 patients with primary hypertension were randomly divided into two groups. The control group was given nifedipine extended release tablets and the experimental group was given nifedipine extended release tablets combined with indapamide tablets. Three months later, the comprehensive efficacy, blood pressure changes, renal function indicators and adverse drug re-actions of the two groups were compared. Results The total effective rate of the experimental group was 91.53%, which was higher than the 75.86% of the control group, with statistically significant difference （P〈0.05）. The experimental group had lower influence on the blood pressure and renal function than the control group （P〈0.01）. The incidence of adverse reactions of the experimental group was 10.17%, The control group was 8.62%, there was not statisticatly sig-nificant.difference （P〉0.05）. Conclusion In the treatment of primary hypertension, nifedipine extended release tablets combined with indapamide tablets shows accurate efficacy in reducing and controlling blood pressure, can increase re-nal blood flow volume to reduce renal damage, and is safe and reliable.

关 键 词：硝苯地平缓释片 吲达帕胺片 原发性高血压 血压水平 肾功能 不良反应 

分 类 号：R544.1[医药卫生—心血管疾病]