低剂量环磷酰胺联合复方黄柏液对尖锐湿疣患者CO_2激光术后复发的影响  

Effects of Low-dose Cyclophosphamide Combined with Compound Huangbai Lotion on Recurrence in Patients with Condylomata Acuminata after CO_2 Laser Therapy

作　　者：胡勇[1] 汤红峰[1] 郑秀芬[1] 王瑞华[1] 黄玲[1] 

机构地区：[1]南方医科大学附属顺德第一人民医院皮肤科,广东佛山528300

出　　处：《中国药房》2014年第32期2997-2999,共3页China Pharmacy

基　　金：广东省佛山市科学技术局科技攻关项目(No.201108209)

摘　　要：目的：观察低剂量环磷酰胺联合复方黄柏液对尖锐湿疣（CA）患者CO2激光术后复发的影响。方法：135例CA患者按随机数字表法分为联合组（38例）、环磷酰胺组（35例）、复方黄柏液组（32例）和对照组（30例）。所有患者均用CO2激光术祛除疣体（包括醋酸白试验阳性区域）后,创面较小的患者给予外用莫匹罗星软膏,创面较大的患者加用左氧氟沙星片0.5 g,口服,qd,连用2~3 d常规治疗。在此基础上,联合组患者给予复方环磷酰胺片50 mg,口服,qd,7 d为1个疗程,连用2个疗程,疗程之间需停药3 d＋皮损局部及周边给予复方黄柏液,创面未愈合者湿敷30 min,创面愈合后改为外洗20 min,bid,连用4周;环磷酰胺组患者给予复方环磷酰胺片（用法用量同联合组）;复方黄柏液组患者给予复方黄柏液（用法用量同联合组）;对照组患者不用其他药物。观察4组患者复发情况及不良反应发生情况。结果：联合组患者复发率〈环磷酰胺组〈复方黄柏液组〈对照组,4组比较差异有统计学意义（P〈0.05）;联合组患者累计复发次数〈环磷酰胺组〈复方黄柏液组〈对照组,4组比较差异有统计学意义（P〈0.05）。联合组患者仅出现1例用药后自觉全身发热外,其他3组患者治疗期间均未见明显不良反应发生。结论：低剂量环磷酰胺联合复方黄柏液较单用环磷酰胺或复方黄柏液,可有效降低CA患者CO2激光术后的复发率,且安全性较好。OBJECTIVE： To observe the effects of low-dose cyclophosphamide combined with Compound huangbai lotion on the recurrence in patients with condylomata acuminate （CA） after COz laser therapy. METHODS： 135 CA patients were randomly divided into combination group （38 cases）, cyclophosphamide group （35 cases）, Compound huangbai lotion group （32 cases） and control group （30 cases）. All patients received COs laser therapy for dispelling wart （acetic acid white test positive area）, and then the patients with small wound were given Mupirocin cream for external use and those with large wound were given Levofloxacin tablet 0.5 g, qd, for 2-3 d roufime treatment. The combination group was given one Compound cyclophosphamide 50 mg orally, qd; a treatment course lasted for 7 d, and all of them received 2 treatment courses; 3 d interval between treatment course＋local ap- plication of Compound huangbai lotion for skin lesion; the lotion was used to wet dressing the wound for 30 min before the wound healed or to wash the skin lesion areas for 20 min after the wound healed, bid, for 4 weeks. The cyclophosphamide group was giv- en Compound cyclophosphamide tablet （usage and dosage were same to combination group）. Compound huangbai lotion group only used Compound huangbai lotion （usage and dosage were same to combination group）. Control group was given routine treatment. The recurrence of disease and ADR were observed in 4 groups. RESULTS： The recurrence rate was in ascending order as combination group, cyclophosphamide group, Compound huangbai lotion group and control group; there were statistical differenc- es among 4 groups （P〈0.05）. The recurrence times was in ascending order as combination group, cyclophosphamide group, Compound huangbai lotion group and control group; there were statistical differences among 4 groups （P〈0.05）. There was no serious ADR during treatment, and only one patient from combination group suffered from transient fever. CONCLUSIONS： Low-dose cyclophosp

关 键 词：环磷酰胺 复方黄柏液 尖锐湿疣 CO2激光术 复发 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]