使用紫杉醇注射液致过敏反应危险因素分析  

Analysis of Risk Factors of Paclitaxel Injection-induced Allergic Reactions

作　　者：蔡红[1] 王怡鑫[1] 程凯[1] 

机构地区：[1]四川省肿瘤医院,成都610041

出　　处：《中国药房》2014年第32期3012-3014,共3页China Pharmacy

摘　　要：目的:探讨化疗药物紫杉醇注射液致过敏反应的相关危险因素,为有效预防过敏反应的发生提供参考。方法:回顾性分析2012年我院输注紫杉醇注射液致过敏反应的62份临床病历,并随机抽取输注紫杉醇注射液未发生过敏反应的102份病历作为对照,对紫杉醇注射液致过敏反应的可能危险因素进行单因素分析及多因素非条件Logistic回归分析。结果:单因素分析结果显示,药物配制浓度、药物过敏史、滴速和预处理方法几个因素未发生与发生过敏反应组间的差异有统计学意义(P<0.05);多因素非条件Logistic回归分析结果显示,上述4个因素均为紫杉醇注射液致过敏反应的危险因素。结论:使用紫杉醇注射液过程中,应当对其致过敏反应的药物配制浓度、药物过敏史、滴速和预处理方法几个危险因素给予关注和干预,以有效预防过敏反应发生。OBJECTIVE： To investigate related risk factors of Paclitaxel injection-induced allergic reaction, and to provide ref- erence for the prevention of the reaction. METHODS： 62 clinical medical records of Paclitaxel injection-induced allergic reaction were analyzed retrospectively in our hospital in 2012; 102 medical records without Paclitaxel injection-induced allergic reaction were included as control; the single factor analysis and multivariate logistic regression analysis were conducted for the potential risk factors of Paclitaxel injection-induced allergic reaction. RESULTS ： Results of single factor analysis showed that there was statistical significance in the concentration of the preparation, history of drug allergy, dropping speed and pretreatment methods between aller- gic reaction group and without allergic reaction group （P〈0.05） ; multivariate regression analysis showed that 4 above factors were risk factor to Paclitaxel injection-induced allergic reaction. CONCLUSIONS： During the application of Paclitaxel injection, great importance should be attached to and intervention should be carried out for the risk factors, including the concentration of prepara- tion, history of drug allergy, pretreatment methods and dropping speed, so as to prevent allergic reactions effectively.

关 键 词：紫杉醇注射液 过敏反应 危险因素 分析 

分 类 号：R969.3[医药卫生—药理学]