宁夏农村居民不同血糖水平与血清矿物元素的关系  

The relationship between blood glucose levels and serum mineral elements of rural residents in Ningxia

作　　者：靳雅男 付海龙[1] 何俊[1] 樊学敏[2] 赵燚[1] 许红霞[1] 刘秀英[1] 张毓洪[1] 

机构地区：[1]宁夏医科大学公共卫生学院流行病与卫生统计学系,宁夏银川750004 [2]宁夏回族自治区人民医院医务科恰好园社区卫生服务站,宁夏银川750001

出　　处：《中华疾病控制杂志》2014年第8期744-747,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81160358);宁夏自然科学基金(NZ1199);宁夏医科大学“博士学位建设学科”开放课题

摘　　要：目的 比较不同血糖水平下血清中14种矿物质元素含量及血清矿物质元素与血糖水平之间的关系。方法 采用分层整群抽样方法在宁夏4个村中共调查3 391人进行体格检查,采集血液样本1 612例进行血液生化指标的测定,采用电感耦合等离子体发射光谱法（inductively coupled plasma emission spectrometry,ICP-AES）测定1 493例血清中14种矿物质元素的含量。结果 血清Cr表现为正常空腹血糖（normal fasting glucose,NFG）组（6.35±2.75）μg/ml显著高于糖尿病（diabetes mellitus,DM）组（5.47±2.09）μg/ml,Sr为空腹血糖受损（impaired fasting glucose,IFG）1组（0.13±0.04）μg/ml高于NFG组（0.11±0.05）μg/ml。Cu含量为NFG组（0.99±2.14）μg/ml低于IFG1组（1.00±2.24）μg/ml、IFG 2组（1.03±2.06）μg/ml和DM组（1.07±2.48）μg/ml三组,DM组高于IFG2组。Ga含量为DM组（0.16±0.08）μg/ml高于NFG组（0.12±0.08）μg/ml、IFG1组（0.13±0.08）μg/ml和IFG2组（0.13±0.08）μg/ml三组。Cu（r=0.083,P=0.017）和Ga（r=0.081,P=0.019）与血糖呈正相关,Cr（r=-0.074,P=0.032）与血糖呈负相关;Cu（r=0.098,P=0.005）和Sr（r=0.087,P=0.012）与胰岛素抵抗指数呈正相关。Cu（OR=1.518,95%CI：1.072~2.151）和Ca（OR=1.618,95%CI：1.076~2.432）是血糖异常的危险因素,且Ca位于最高浓度时,血糖异常的风险最高;Sr（OR=0.800,95%CI：0.678~0.944）是其保护因素。结论 血清铜、镓、铬与血糖水平密切相关,并且铜、锶和钙是血糖异常的独立影响因素。Objective To compare the concentrations of 14 mineral elements in different blood glucose levels, and to analyse the relationship between serum mineral elements and the blood glucose. Methods A total of 3 391 persons from four villages in Ningxia were selected by the stratified cluster sampling method. A number of 1 612 blood samples were collected. Inductively coupled plasma emission spectrometry （ICP-AES） was used to determine the contents of 14 serum mineral elements in 1 493 subjects. Results The serum chromium in NFG（6. 35 ±2.75） μg/ml was significantly higher than that in DM （5.47 ±2.09） μg/ml and the serum strontium in IFG1 （0. 13 ±0. 04） was higher than that in NFG（0. 11 ±0.05 ） μg/ml. Serum copper in NFG （0. 99 ±2. 14） μg/ml was lower than IFG1 （ 1.00 ±2. 24 ） μg/ml, IFG2 （ 1.03 ± 2. 06） μg/ml and DM（ 1.07 ±2. 48）μg/ml in the groups and serum copper in DM was higher than IFG2. Serum gallium in DM group（0. 16 ±0.08） μg/ml was higher than the three groups of NFG （0. 12 ±0.08） μg/ml, IFGI（0. 13 ±0.08） μg/ml and IFG2 （0. 13 ±0. 08） μg/ml. Partial correlation analysis showed that serum copper（r =0. 083, P =0. 017） and gallium （r = 0. 081, P = 0. 019） were positively correlated with blood sugar. While serum chromium （r = -0. 074, P = 0. 032） was negatively correlated with blood sugar; While serum copper（r =0. 098,P =0. 005） and strontium（r =0. 087, P = 0. 012） indexes were positively correlated with insulin resistance. Logistic regression analysis showed that Cu （OR = 1. 511% ,95% CI：I. 072-2. 151 ） and Ca（ OR = 1. 618,95% CI： 1. 076-2. 432） were risk factors for abnormal blood sugar, when Ca reached the highest concentration, the risk of abnormal blood sugar showed highest. As a contrast, Sr （ OR = 0. 800,95% CI：0. 678-0. 944） was the protective factor of abnormal blood sugar. Conclusions The serum copper, gallium and chromium are closely related to blood sugar levels. Copper, strontium and calcium

关 键 词：血糖 矿物质 元素 

分 类 号：R587.1[医药卫生—内分泌] R181.2[医药卫生—内科学]