活心方对冠心病心绞痛患者临床疗效及血清VEGF水平的影响  

Effects of Huoxin Prescription on Therapeutic Efficacy of Angina Pectoris of Coronary Heart Disease and Serum Level of VEGF

作　　者：张超 姚成增[2] 蒋梅先[2] 胡琪祥[2] 关敬树 曹飞[3] 

机构地区：[1]宝山区中西医结合医院心内科,上海201900 [2]上海中医药大学附属曙光医院心内科,上海200021 [3]上海市普陀区人民医院中医科,上海200060

出　　处：《中国实验方剂学杂志》2014年第16期180-183,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市卫生局基金项目(ZYSNXD-CC-HPGC-JD-003);上海市科委基金项目(05dz19506);上海市卫生系统优秀青年人才培养计划项目(XYQ2011064)

摘　　要：目的:观察中药活心方加载治疗对冠心病心绞痛患者的临床疗效及血清血管内皮生长因子(VEGF)水平的影响。方法:将60例冠心病心绞痛患者随机分为两组,中药加载组(n=31)和对照组(n=29);对照组采用西药常规治疗,中药加载组在西药常规治疗的基础上给予活心方加载治疗。对两组患者的中医证候疗效、心绞痛疗效、左室射血分数(LVEF)及血清VEGF水平进行观测。结果:经治疗后,与对照组相比,中药加载组患者的中医证候积分进一步降低(P<0.05),中医证候疗效和心绞痛疗效总有效率更高(P<0.05);与治疗前相比,中药加载组患者治疗后LVEF及血清VEGF水平得以提高(P<0.05,P<0.01),而对照组无显著性变化,治疗后组间有显著差异(P<0.05)。结论:活心方加载治疗可进一步改善冠心病心绞痛患者的临床症状,提高临床疗效,并增加患者LVEF和提高其血清VEGF水平。Objective：To observe the effects of Huoxin prescription on therapeutic efficacy of angina pectoris of coronary heart disease and serum level of vascular endothelial growth factor （VEGF）.Method：Sixty patients with angina pectoris were randomly assigned into traditional Chinese medicine （TCM） group （31 patients） and control group （29 patients）.All the patients involved were treated with western medicine,and the patients in TCM group were given the Chinese medicine,Huoxin prescription,in addition.Then we observed the therapeutic efficacy of the TCM syndrome and angina pectoris,left ventricular ejection fraction （LVEF） and serum level of VEGF.Result：Compared with the control group,TCM syndrome score of the patients in TCM group was further decreased （P ＜ 0.05）,and the total efficiency of TCM syndrome and angina pectoris were higher （P ＜ 0.05）.Compared with before treatment,the LVEF and serum level of VEGF of the patients in TCM group were increased （P ＜0.05,P ＜ 0.01）,and there were significant differences between the two groups after treatment （P ＜ 0.05）.Conclusion：The symptoms of the patients in TCM group were further improved by treating with Huoxin prescription,and the therapeutic efficacy was further increased as well.Simultaneously,the LVEF and serum level of VEGF of the patients in TCM group were increased by treatment of Huoxin prescription.

关 键 词：活心方 冠心病心绞痛 临床疗效 血管内皮生长因子 

分 类 号：R287.6[医药卫生—中药学]