结核性胸膜炎患者血清IFN-γ表达的meta分析  

Meta-analysis on the expression of IFN-γin the blood serum of potieats with tuber culous peurisy

作　　者：唐文芳[1] 刘日辉[2] 张亚男[1] 王敏[1] 刘丽莉[3] 王珂[1] 

机构地区：[1]吉林大学第二医院呼吸内科,吉林长春130041 [2]吉林大学公共卫生学院流行病与卫生统计学教研室,吉林长春130021 [3]吉林大学第一医院肝胆胰内科,吉林长春130021

出　　处：《中国实验诊断学》2014年第8期1278-1282,共5页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨IFN-γ在结核性胸膜炎患者血清中的表达及意义。方法计算机检索PubMed、Ovid、Elsevier、CNKI、维普、CBM、万方等中英文数据库,检索血清IFN-γ与结核性胸膜炎的病例-对照研究。按照纳入与排除标准选择研究文献,同时对文献进行质量评价,以加权均数差值(WMD)及其95%CI为效应评价指标,应用RevMan5.1进行Meta分析。结果共有10篇病例对照研究纳入研究,包括结核性胸膜炎426例,恶心胸水323例,其他炎症胸水97例,健康人219例。Meta分析结果显示:结核性胸膜炎血清IFN-γ要显著高于恶性胸膜炎[WMD=5.78,95%CI(2.82,8.75)]、其他胸膜炎[WMD=4.66,95%CI为(0.08,9.24)]及健康人[WMD=5.24,95%CI为(3.33,7.15)]。结论血清INF-γ高表达可能与结核性胸膜炎发病有关联,有望将血清INF-γ检测应用于结核性胸膜炎的筛查和诊断。Objective To study the expression and clinical significance of Interferon-gamma（IFN-Y）in blood serum for tuberculous exadative pleurisy.Methods The original case-control study was retrieved form PUBMED 、Ovid 、Elsevier、CNKI、Weipu database、Wanfang database and so on.The established items were used for the standard of selection and quality assessment.Review Manger 5.1was used to analyze pooled weighted mean difference（WMD）and confidence interval（CI）.Results Though literature retrival,ten articles were selected,including 426 patients with tubercuous pleurisy,323 patients with malignant pleural effusion,97 patients with other inflammatory effusion and 219 healthy persons.The result indicates IFN-Y in blood serum for tubercuous pleurisy was much higher than malignant pleural effusion[WMD=5.78,95%（2.82,8.75）],other inflammatory effusion[WMD=4.66,95%（0.08,9.24）],healthy persons[WMD=5.24,95%（3.33,7.15）].Conclusion The high expression of IFN-Y in blood serum may related to tubercuous pleurisy can be used as the means of screening and diagnosis.

关 键 词：胸膜炎 结核 IFN-Γ META分析 

分 类 号：R521.7[医药卫生—内科学]