乙肝患者血清TNF-α、IL-6、IL-10的水平及临床意义  

Study on the variation and clinical significance of serum TNF-α、IL-6and IL-10of patients with chronic hepatitis B

作　　者：肖时湘[1] 韩涛[1] 李岩[1] 阚志超[1] 

机构地区：[1]天津市第三中心医院消化科,天津300170

出　　处：《中国实验诊断学》2014年第8期1283-1285,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨乙肝患者血清中的TNF-α、IL-6、IL-10的表达水平及临床意义。方法选取2009年1月-2012年12月在本院进行治疗的128例乙型肝炎患者为病例组,其中包括急性乙型肝炎患者14例,轻度慢性乙性肝炎患者29例,中度慢性乙性肝炎患者34例,重度慢性乙性肝炎患者24例,乙肝后肝硬化患者27例,同时选择进行体检的40名健康人为对照组,将两组人的血清TNF-α、IL-6、及IL-10含量进行测量和分析。结果病例组血清TNF-α和IL-6含量高于对照,随着病程的进展血清TNF-α及IL-6的含量上升,病例组血清IL-10含量低于对照组。P<0.05,有显著性差异。结论乙肝患者血清TNF-α、IL-6均呈现升高的状态,而IL-10呈降低的状态,其含量变化可预测病情进展及病情的严重程度。Objective To explore the clinical significance of changes on serum levels of TNF-α,interleukin-6（IL-6）the clinical significance of changes on serum levels of inter and interleukin-10（IL-10）in patients with chronic hepatitis B（CHB）.the clinical significance of changes on serum levels of inter Methods 128 patients with chronic hepatitis B in our hospital from January 2009 to December 2012 were selected as observation group,and 40 healthy personnel at the same time were selected as control group,then the content of serum TNF-α、IL-6and IL-10 of two groups were analyzed and compared.Results The content of serum TNF-αand IL-6of observation group were all higher than those of control group,With the progression of serum TNF-αandIL-6increased.The content of serum IL-10 of observation group was lower than those of control group,With the progression of serum IL-10 decreased.all P0.05,there were all significant differences.Conclusion The serum TNF-α、IL-6of patients with chronic hepatitis B are all higher,and IL-10 is lower,and it has clinical significance for understanding the severity of disease.

关 键 词：乙肝 血清 TNF-Α IL-6 IL-10 

分 类 号：R512.62[医药卫生—内科学]