血与尿胱抑素C在糖尿病早期肾损伤中的意义  

Significance for determination of blood and urine cystatin C with liquid immune colloidal gold technique in early renal injury of Diabetes Mellitus

作　　者：庄严 陈志友 王黎敏 

机构地区：[1]南山区蛇口人民医院,广东深圳518000

出　　处：《中国实验诊断学》2014年第8期1304-1306,共3页Chinese Journal of Laboratory Diagnosis

基　　金：深圳市南山区科技资助项目2011-030

摘　　要：目的探讨胶体金法检测血与尿胱抑素C在糖尿病早期肾损伤中的意义。方法通过检测114例正常人与116例糖尿病患者血及尿中胱抑素C(Cys C)与β2微球蛋白(β2-MG),采用对比分析,评价正常人群清晨随机尿中尿胱抑素C水平,以及不同糖尿病组(尿微量白蛋白正常及异常组)血、尿胱抑素C与血、尿β2微球蛋白之间的关系。结果在糖尿病早期肾损伤中检测血或尿胱抑素C与检测血及尿β2微球蛋白,经过对比分析,二者均有显著的正相关性;但是单独检测尿胱抑素C,与尿β2微球蛋白相比,二者间没有统计学差别。结论在糖尿病早期肾损伤中检测血或尿胱抑素C同样是一个理想的诊断指标。Objective To detect cystatin C with liquid immune colloidal gold technique in serum and urine and study the significance in early renal injury of patients with Diabetes Mellitus.Methods we detected cystatin C（Cys C）with liquid immune colloidal gold technique and compared with β2—microglobulin（β2-MG）in serum and urine for 114 normal people and 116 patients with Diabetes Mellitus,then evaluated the level of random urine Cys C for normal people in the morning and the relationship of Cys C andβ2-MG in different patients groups with Diabetes Mellitus（normal and unnormal mALB）.Results It had a significant positive correlation by statistal analysis for detecting Cys C andβ2-MG in serum and urine of patients with early renal injury of Diabetes Mellitus;but there is no statistical difference between only detecting urine Cys C andβ2-MG.Conclusion It will be an ideal diagnostic indicator for detecting serum and urine Cys C in patients with early renal injury of Diabetes Mellitus.

关 键 词：胱抑素C 糖尿病 肾损伤 

分 类 号：R587.1[医药卫生—内分泌] R446.6[医药卫生—内科学]