高乌甲素新型制剂的研究进展  

Research progress on new preparations of lappaconitine

作　　者：李思思[1] 张洪兵[1] 朱雪瑜[2] 赵志全 张铁军[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院,天津300193 [3]中药制药共性技术国家重点实验室,山东临沂276006

出　　处：《现代药物与临床》2014年第7期818-823,共6页Drugs & Clinic

基　　金：国家重点基础研究发展计划(973计划)资助项目(2012CB724001)

摘　　要：高乌甲素是从高乌头Aconitum sinomontanum Nakai内提取的二萜类生物碱,为非阿片类镇痛药,临床上常使用高乌甲素的氢溴酸盐用于中度以上疼痛的治疗。由于高乌甲素的水溶性差、对光照较敏感,其理化性质决定了传统制剂的临床应用受到一定的限制,使得新型制剂的研究成为一种趋势。近年来,高乌甲素的不同新型制剂被不断开发以满足不同的治疗目的,综述了近几年高乌甲素新型制剂方面的研究进展,主要从其药物载体制剂、缓控释制剂及速释制剂3个方面进行了分类、归纳和总结,对现有问题进行分析并为后续研究提供一些参考。Lappaconitine is a kind of diterpenoid alkaloids extracted fromAconitum sinomontanum Nakai. As a non-opioid analgesic, its hydrobromide is commonly used in the treatment of moderate to severe pain clinically. The clinical application of lappaconitine traditional preparations was limited due to its poor water solubility and sensitivity to light, which made the study of new agents become a trend. In recent years, different formulations of lappaconitine are constantly developed to meet different therapeutic purposes. Research progress on new preparations of lappaconitine was reviewed in recent years. And the information was classified and summarized mainly from three aspects of carrier, sustained-release and immediate-release preparations, to analyse the existing problems and provide some references for further study.

关 键 词：高乌甲素 理化性质 载体制剂 缓释制剂 速释制剂 

分 类 号：R944[医药卫生—药剂学]