依诺沙星-水滑石纳米复合材料的制备、表征及热稳定性  

Preparation,characterization and thermostability of enoxacin-layered double hydroxides nanocomposite

作　　者：姬海婷 郝秀华[1] 王志巧[1] 杨玉霞[1] 刘翠娟[2] 孙宇佳[3] 

机构地区：[1]吉林大学药学院,吉林长春130021 [2]佳木斯大学药学院,黑龙江佳木斯154007 [3]黑龙江中医药大学研究生学院,黑龙江哈尔滨150036

出　　处：《沈阳药科大学学报》2014年第8期602-605,617,共5页Journal of Shenyang Pharmaceutical University

基　　金：黑龙江省教育厅科学技术研究项目基金资助(12531693)

摘　　要：目的研究依诺沙星-水滑石纳米复合材料的制备、表征及热稳定性。方法依据水滑石层间阴离子可交换性,将依诺沙星药物阴离子插层组装到水滑石的层间,并对产物的结构和热稳定性进行表征和分析。结果通过对图谱及数据的分析可知,依诺沙星药物阴离子是沿水平方向以单层方式排布于层间,与主体层板通过氢键与静电作用形成超分子结构,插层产物比依诺沙星原料药的热分解温度明显提高。结论水滑石作为药物载体可以提高药物的热稳定性,有很好的发展前景。Objective To prepare and identify enoxacin-layered double hydroxides nanocomposite, and study it＇s thermostability. Methods Enoxacin anionic was intercalated in layered double hydroxides by ion-ex- change of layered double hydroxides, then the structure and thermostability of the product were identified and analyzed. Results Analysis of the data and map proved that enoxacin anionic was arranged monolayer be- tween layers along the horizontal direction. The supramolecular structure was formed through hydrogen bonding and electrostatic attraction of the host and the guest. Thermal decomposition temperature of the product was significantly higher than enoxacin. Conclusions Layered double hydroxides can improve thermo- stability as drug carder, and it has wide development prospect.

关 键 词：水滑石 依诺沙星 离子交换 热稳定性 

分 类 号：R284.1[医药卫生—中药学]