超早期高压氧对急性脑外伤大鼠的疗效  

The study of hyerbaric oxygen on experimental traumatic brain injury in rats

作　　者：吴雅丽[1] 薛连璧[2] 

机构地区：[1]首都医科大学石景山教学医院北京市石景山医院神经内科,北京100043 [2]首都医科大学附属北京天坛医院高压氧科,北京100050

出　　处：《中日友好医院学报》2014年第4期226-228,共3页Journal of China-Japan Friendship Hospital

基　　金：北京市优秀人才专项培养经费资助项目(2002)

摘　　要：目的:研究高压氧治疗大鼠创伤性脑损伤的疗效及其保护机制。方法:健康成年雄性SD大鼠24只,随机分为对照组和高压氧治疗组。采用Feeney法制造局灶性脑创伤模型,在相应的时间点处死大鼠,观察脑组织含水量及脑组织核转录因子κB(NF-κB)表达的变化。结果:高压氧治疗后,对照组的脑组织含水量显著高于治疗组,对照组的NF-κB的表达显著高于治疗组。结论:高压氧单次9h超早期治疗能减轻脑水肿,有显著的脑保护作用,初步显示了其疗效,其机制可能通过降低NF-κB起到脑保护作用。Objective：To explore the effect of hyperbaric oxygen therapy （HBOT）in the treatment of traumatic brain injury in rats and its protective mechanism.Methods：Rats were randomly divided into control group and HBOT group.Rats were undergone moderate brain injury.Fourteen hours and 3 days after injury,the water content and the expression of nuclear factor-kappa B （NF-KB）were measured.Results：The water content of brain tissue in control group was significantly higher than that in the treatment group.The expression of NF- KB in the control group was significantly higher than that in the treatment group （P〈0.01）.Conclusion： Hyperbaric oxygen can reduce the water content of brain tissue ,there is significant brain protection effect,and its mechanism may be through decreasing the expression of NF-KB in the brain.

关 键 词：创伤性脑损伤 高压氧 大鼠 核转录因子 

分 类 号：R459.6[医药卫生—治疗学]