白细胞介素-1基因的多态性与白塞病易感关联性的Meta分析  

A Meta analysis of association between IL.1 gene polymorphisms and Beh^et disease susciptibility

作　　者：吴静[1] 崔裕波[2] 侯光辉[3] 王超[2] 张日佳[2] 祁冰[2] 

机构地区：[1]暨南大学医学院眼科研究所,广州510630 [2]暨南大学附属第一医院眼科,广州510632 [3]暨南大学附属珠海医院眼科,珠海519000

出　　处：《中华实验眼科杂志》2014年第8期743-747,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：珠海市科技计划项目（2013D0401990017）

摘　　要：背景白细胞介素-1（IL-1）α-889C／T、IL-1B-511C／T、＋3962C／T和IL-1Ra-2是IL-1基因的不同位点。IL-1基因的多态性与白塞病之间的潜在相关性已经在不同的人群中进行了研究，但研究结果存在一定的争议。目的对已发表的关于IL-1基因多态性与白塞病之间关联性的文献进行二次分析，探讨儿IL-1基因多态性是否增加白塞病的易感性。方法按照检索策略检索2013年5月31日之前公开发表的关于 IL-1基因多态性与白塞病之间关联性的研究文献，检索途径包括Medline、EMBASE、CochraneLibrary、Webofknowledge、GoogleScholar、中国知网和万方数据库，发表语种限于英文和中文，研究设计包括病例对照研究。筛选出符合标准的文献，根据Newcastle-OttawaScale（NOS）量表（共9分）评价纳入文献的研究质量。分析IL-1α-889TT基因型、IL-1β-3962C等位基因、IL-1p-511T表型基因和IL-1Ra-2等位基因与白塞病易感性间的关联性，用RevMan5．0统计学软件进行统计学分析。对7篇研究中异质性低（12〈50％）的指标采用固定效应模型评价各指标的合并效应量，异质性高（12〉50％）的指标用随机效应模型评价合并效应量。结果共检索到相关文献370篇，经过阅读摘要和全文共纳入7篇符合纳入标准的研究文献，NOS量表评分均≥8分。7篇文献共包括白塞病患者499例和正常人708名，结果发现IL-1β-3962C等位基因多态性增加白塞病的风险（OR=1．41，95％CI：1．06～1．88，P=0．02），IL-1α-889TT表型基因的多态性降低白塞病的风险（OR=0．61，95％CI：0．40～0．92，P=0．02），而IL-1B-511T等位基因（OR=0．84，95％CI：0．58～1．23，P=0．38）和IL-1Ra-2等位基因（OR=1．25，95％CI：0．50～3．14，p=0．63）与白塞病之间均无明显关联。结论儿IL-1基因多态性与白塞病易感性之间可能具有一定的相关性，但还需要大样本量的临床研究进�Background Interleukin （IL）-lα-889C/T, IL-1β-511C/T, ＋ 3962C/T and IL-1Ra-2 are different morphology of single nucleotide of interleuki-1 （ IL-1 ）. The potential relationship of IL-1 polymorphisms with Behget disease has been studied in several populations and groups. However, study outcomes are controversial for a long duration. Objective This Meta-analysis was to determine whether the IL-1 gene polymorphisms is associated with the pathogenesis and development of Beh^et disease. Methods The literature of the assoiation between IL-1 polymorphisrns and Beh^et disease was retrieved from Medline, EMBASE, Cochrane Library, Web of knowledge, Google Scholar, Wanfang and CNKI databases. All the published original articles （case-control studies） were reviewed with the deadline May 31,2013, and the languages were limited to English and Chinese. Included reports were evaluated based on Newcastle-Ottawa Scale （NOS） score. The potential influence of IL-lα-889TT gene, IL-1β-3962C, IL-lβ-511T and IL-1Ra-2 polymorphisms on Behcet disease were analyzed. RevManS. 0, the Cochrane collaborationsoftware program ,was used to prepare and complete this review. The effect size was assessed using fixed effect model in the index with lower heterogeneity （12 〈50% ） or randomized effect model in the index with higher heterogeneity （12〉50% ）. Results The literature search resulted a total of 370 cases-controlled studies,and 7 studies met the included criteria,with the NOS scores~〉8. The total patients were 499 and normal controls were 708. Meta-analysis was performed on several populations. Overall,the polymorphisms of IL-1 ^-3962C allele increased the susciptibility of Beh^et disease （ OR = 1.4l, 95 % CI： 1.06-1.88, P = 0.02 ） , and IL-1ct-889TT genotype reduced the risk of Beh^et disease （OR = 0.61,95% CI：O. 40-0.92, P = 0. 02 ）. However, There was no significant association between variants of IL-113-511T allele （ OR = O. 84,95 % CI ： 0.58-1.23, P = O. 38 ） or IL-1 RA-2 allele （ OR

关 键 词：白塞病 白细胞介素-1 基因多态性 META分析 

分 类 号：R597.9[医药卫生—内科学]