正常与法洛四联症胎儿心脏主、肺动脉径线 z-score值的对比研究  

Comparison between the aorta and pulmonary artery dimensions z-score in fetus with tetralogy of Fallot and normal fetus

作　　者：吴利红[1] 谢红宁[1] 李岚[1] 汪南[1] 郑菊[1] 朱云晓[1] 

机构地区：[1]广州,中山大学附属第一医院超声科510080

出　　处：《中华超声影像学杂志》2014年第7期577-580,共4页Chinese Journal of Ultrasonography

基　　金：国家科技支撑计划（2006BAll05A04）;国家自然基金面上项目（81071166）;广东省科委科技计划资助项目（20098080701061）

摘　　要：目的超声探讨正常与法洛四联症（tetralogy of Fallot，TOF）胎儿主、肺动脉径线的差异。方法应用时间一空间关联成像技术测量329例正常胎儿和43例TOF胎儿主动脉内径（Ao）及主肺动脉内径（PA），建立正常胎儿Ao、PA z-score模型，比较两组Ao、PA z-score值及PA／Ao值差异。结果两组Ao、PA z-score值及PA／Ao值差异有统计学意义（P＜0．0001），TOF组Ao z-score值均＞＋2 z-scores，PA／Ao值均分布于95％CI之外，48．84％PA z-score值＜-2z—scores。结论胎儿时期TOF大血管径线改变以Ao增宽及PA／Ao比值减小为主要表现，有望成为产前超声诊断指标。Objective To establish z-score model for fetal aorta （Ao） and pulmonary artery （PA） dimensions base on fetal femur length （FL）, then to evaluate them in prenatal diagnosis of tetralogy of Fallot （TOF）. Methods Three hundred twenty-nine normal fetuses and 43 fetuses with TOF were involved, Ao and PA dimensions were measured for all cases offline after cardio-spatiotemporal image correlation （STIC） volume acquisition, and PA to Ao ratio （PA/Ao） was calculated. Normal Ao and PA dimensions z-score models were constructed by using first standard regression analysis using FL as independent variable.Subsequently,the three parameters between normal and TOF fetuses were compared. Results The models use to calculate z-score for Ao and PA dimensions were constructed, FL had close correlation with fetal Ao and PA dimensions.Compared with normal fetuses, the mean z-scores of Ao, PA and PA/Ao ratio were statistical different in TOF fetuses.All Ao z-scores were 〉＋ 2 z-scores and all the PA/Ao ratio were 〈 the 95% CI in TOF group,however,only 48.84%（21/43） PA z-scores of TOF cases were 〈 - 2 z-scores.Conclusions The Ao and PA dimensions z-score can provide quantitative evidence in prenatal diagnosis of TOF. Aortic dilatation and abnormal PA/Ao ratio are the main performances in fetal TOF and would be markers for prenatal diagnosis of TOF.

关 键 词：超声检查 产前 法乐四联症 主动脉 肺动脉 时间-空间关联成像 

分 类 号：R714.5[医药卫生—妇产科学]