超声造影定量分析在移植肾急性排异中的应用研究  

Quantitative analysis of contrast-enhanced ultrasound in acute rejection of kidney graft

作　　者：周盛[1] 齐青[1] 何婉媛[1] 季正标[1] 金赟杰[1] 王文平[1] 

机构地区：[1]上海,复旦大学附属中山医院超声科上海市器官移植重点实验室上海市影像医学研究所200032

出　　处：《中华超声影像学杂志》2014年第7期605-608,共4页Chinese Journal of Ultrasonography

基　　金：上海市自然科学基金（13ZR1406400）;上海市重点学科建设项目（B112）

摘　　要：目的探讨超声造影定量分析技术在移植肾急性排异中的应用价值。方法102例肾移植患者，包括移植肾功能正常组67例，急性排异组35例。常规超声测量段间、叶间动脉的收缩期峰值流速（PSV）及阻力指数（RI），超声造影定量分析移植肾整体灌注曲线形态，然后选取皮质、髓质、段间动脉及叶间动脉四个感兴趣区，软件生成定量参数：造影剂上升时间（RT）、达峰时间（TTP）、平均渡越时间（mTT）。计算皮质、髓质与叶间动脉的造影剂灌注时间差△RT皮-叶、△RT、△TTP皮-叶、△TTP及△mTT皮-叶、△mTT。结果叶间动脉PSV在两组间差异有统计学意义（P＜0．05）。移植肾整体灌注曲线形态、△RT皮-叶及△TTP皮-叶在两组间差异有统计学意义（P＜0．05）。结论超声造影定量分析技术可为移植肾急性排异提供定量诊断方法。Objective To study the value of quantitative analysis of contrast-enhanced ultrasound in diagnosing acute rejection of kidney graft. Methods Sixty-seven patients with normal kidney grafts and thirty-five patients with acute rejection were recruited.In conventional ultrasound,the peak systolic velocity （PSV） and resistance index （RI） of segmental artery and interlobar artery were measured. In quantitative analysis of contrast-enhanced ultrasound, four regions of interest including renal cortex, medulla, segmental artery and interlobar artery were drew and three parameters including rising time（RT）,time to peak（TTP） and mean transit time（mTT） were obtained.In addition, the difference in RT, TTP and mTT between the renal cortex and interlobar artery, as well as medulla and interlobar artery were calculated. Results The differences of PSV in interlobar artery between the two groups were statistically significant （ P〈0.05）.The time-intensity curves of the whole kidney grafts,and the difference in RT and TTP between the renal cortex and interlobar artery were statistically different between two groups （ P〈0.05）.Conclusions Quantitative analysis of contrast-enhanced ultrasound proved a quantitative method for diagnosing kidney allograft acute rejection.

关 键 词：超声检查 微气泡 肾移植 移植物排斥 

分 类 号：R445.1[医药卫生—影像医学与核医学] R699[医药卫生—诊断学]