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作 者:章体玲[1,2] 光雪峰[1,2] 张伟华[1,2] 鲁一兵[1,2]
机构地区:[1]昆明医科大学附属延安医院心内科 [2]云南心血管病医院,云南昆明650051
出 处:《昆明医科大学学报》2014年第9期131-133,共3页Journal of Kunming Medical University
摘 要:目的研究阿托伐他汀对高血压合并房颤患者脉压及动脉弹性的影响.方法选取脉压≥60 mmHg的高血压合并房颤患者70例,随机分为观察组(40例)和对照组(30例),观察组给予阿托伐他汀联合降压治疗.在用药前及用药后24周分别检测患者血压、大动脉弹性指数C1、小动脉弹性指数C2.比较2组患者脉压及动脉弹性改善情况.结果观察组治疗24周后脉压下降较对照组明显,2组间差异有统计学意义(P<0.05);观察组小动脉弹性指数C2增加显著,差异有统计学意义(P<0.05),大动脉弹性指数C1无显著改变(P>0.05).对照组C1、C2无显著改变(P>0.05).结论阿托伐他汀能明显改善患者动脉弹性,有效降低高血压合并房颤患者脉压.Objective To observe the curative effects of atorvastation on the pulse pressure and arterial elasticity of hypertension with atrial fibrillation. Methods 70 patients(pulse pressure ≥ 60 mmHg) were randomly divided into the control group and the observation group. The observation group(40 cases) was treated with atorvastatin combined with antihypertensive therapy. Before treatment and 24 weeks after drugs,the patient's blood pressure,arterial elasticity index C1 and small artery elasticity index C2 were detected. The improved situation of pulse pressure and arterial flexibility in the two groups were compared. Results Compared with the control group, pulse pressure was dramatically reduced in the observation group after 24 weeks of treatment, and the differences were statistically significant(P〈0.05). C2 of the observation group was obviously higher than that of the control group(P〈0.05),while no significant change was observed in arterial elasticity index C1(P〈0.05).In the control group,there were no significant changes in C1 and C2(P〉0.05). Conclusion Atorvastatin can significantly improve the arterial elasticity,reduce the pulse pressure of hypertensive patients with atrial fibrillation.
分 类 号:R544.1[医药卫生—心血管疾病]
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