Clinical and experimental studies on polyherbal formulations for diabetes: current status and future prospective  

作　　者：Ahmad Ghorbani 

机构地区：[1]Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences

出　　处：《Journal of Integrative Medicine》2014年第4期336-345,共10页结合医学学报（英文版）

基　　金：support was provided by Mashhad University of Medical Sciences, Iran

摘　　要：Diabetes is a leading cause of morbidity an active search for antidiabetic drugs with greater and mortality in the world. There is currently effectiveness with fewer and less adverse side effects. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. This paper presents what is known about the efficacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed.Diabetes is a leading cause of morbidity an active search for antidiabetic drugs with greater and mortality in the world. There is currently effectiveness with fewer and less adverse side effects. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. This paper presents what is known about the efficacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed.

关 键 词：diabetes mellitus hypoglycemic agents plants  medicinal review 

分 类 号：R285[医药卫生—中药学]