UA患者血清血管生成因子的改变研究  

The study of the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris

作　　者：张芳[1] 陈玉林[1] 蒋跃绒[2] 

机构地区：[1]杭州,浙江杭州师范大学附属医院心血管内科310015 [2]中国中医科学院西苑医院心血管中心

出　　处：《中国医师杂志》2014年第7期901-903,共3页Journal of Chinese Physician

基　　金：国家自然科学基金（30901949）

摘　　要：目的探究不稳定性心绞痛（UA）患者血清中血管生成因子质量浓度的变化。方法选取2011年1月至2013年9月在本院心血管内科确诊并接受治疗的不稳定型心绞痛患者60例为实验组，根据葡萄糖耐量试验（OGTY）结果再分为糖尿病组（A组，n=20）和非糖尿病组（B组，n=40）。对照组为在本院体检的健康人，共30例。收集血清，然后使用蛋白芯片检测血清中血管内皮生长因子（VEGF）、血管形成蛋白-1（angiopoietin-1）、血管形成蛋白-2（angiopoietin-2）、血管生成素（angio—genin）、血管抑素（angiostatin）、碱性成纤维细胞生长因子（bFGF）和血小板衍生生长因子BB（PDGF-BB）质量浓度，并比较各组间的上述指标差异。结果在UA患者血清中VEGF[（325．2±210．1）pg／ml]和angiopoietin-2[（3031．3±1865．5）Pg／ml]质量浓度较对照组显著增高（P＜0．05），而angiopoietin-1、angiogenin、angiostatin、bFGF和PDGF—BB的两组之间比较差异无统计学意义（P＞0．05）。糖尿病组与非糖尿病组间的7项主要血清血管生成因子浓度差异无统计学意义（P＞0．05）。结论UA患者血清中血管内皮生长因子、血管形成蛋白-2浓度明显增高，糖尿病并不影响这种变化。Objective To explore the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris. Methods A total of 60 patients with unstable angina pectoris was eligible for study and divided into diabetes group （A group, n = 20） and non-diabetes group （B group, n = 40 ）. Another 30 general-matched healthy subjects from medical examination center were enrolled as control group. Serum samples were collected, and serum concentrations of vascular endothelial growth factor （VEGF）, angiopoietin-1, angiopoietin-2, angiogenin, angiostatin, basic fibroblast growth factor （bFGF）, and platelet-derived growth factor-BB （PDGF-BB） were measured by cytokine array technology and compared between the groups. Results Compared with the control group, the serum concentrations of VEGF [ （325.2 ±210. 1 ）pg/ml ] and angiopoietin-2 [ （3031.3±1865.5 ）pg/ml ] were significantly increased in patients with unstable angina pectoris （ both P〈0. 05 ）. Whereas, no significant differences in serum concentrations of angiogenin, angiopoietin-1, angiostatin, bFGF, and PDGF-BB were detected between control group and patient groups. There were no significant differences in serum concentrations of above all 7 biomarkers between diabetes group and non-diabetes group. Conclusions Serum concentrations of VEGF and angiopoietin-2 were increased in patients with unstable angina pectoris, and diabetes didn t affect the increases in serum concentrations of VEGF and angiopoietin-2 caused by unstable angina peetoris.

关 键 词：心绞痛 不稳定型 血管内皮生长因子A 血液 血管生成素类 血液 成纤维细胞生长因子2 血液 糖尿病 

分 类 号：R541.4[医药卫生—心血管疾病]