中老年人群高静息心率对颈动脉斑块稳定性的影响  

Effects of high resting heart rate on the stability of carotid artery plaque in a middle and advanced aged population

作　　者：黄宇玲[1,2] 王志军[2] 刘雪梅[3] 李雯[3] 王迈[3] 陈朔华[4] 吴寿岭[5] 

机构地区：[1]天津医科大学泰达国际心血管病医院,300450 [2]河北联合大学附属医院心内科 [3]河北联合大学附属开滦总医院超声科 [4]河北联合大学附属开滦总医院重症医学科 [5]河北联合大学附属开滦总医院心内科

出　　处：《中华医学杂志》2014年第29期2308-2311,共4页National Medical Journal of China

基　　金：国家科技支撑计划项目（2008BAI52B03）

摘　　要：目的 探讨中老年人群高静息心率对颈动脉斑块稳定性的影响.方法 在参加2006-2007年健康体检的开滦（集团）有限责任公司在职及离退休职工101 510人中分层随机抽取5 852人作为观察人群,于2010-2011年对观察人群进行健康体检,同时进行了颈动脉超声检查,采用Logistic回归分析颈动脉稳定和不稳定斑块的影响因素.结果 最终纳入分析4 894例中老年人群（男2 945例,女1 949例）,年龄40 ～ 95岁.低静息心率组颈动脉稳定、不稳定斑块检出率分别为25.7％、25.4％,高静息心率组颈动脉稳定、不稳定斑块检出率分别为23.8％、33.2％;调整其他危险因素后,高静息心率组发生不稳定斑块风险比低静息心率组增加29％,其OR值为1.290（95％ CI1.039 ～1.062）.结论 高静息心率能增加中老年人群颈动脉不稳定斑块的发生风险.Objective To explore the effect of high resting heart rate （RHR） on the stability of carotid artery plaque in a middle and advanced aged population.Methods During 2010-2011,a total of 5 852 participants were selected randomly from 101 510 workers of a Tangshan Kailuan company.RHR was measured and carotid artery ultrasound performed to detect the carotid artery plaque.Logistic regression was performed to analyze the influencing factors of carotid artery stable and unstable plaque.Results There were 4 894 subjects aged 40-95 years,including 2 945 males and 1 949 females.The detection rates of carotid artery stable and unstable plaque were 25.7％ and 25.4％ in low RHR group versus 23.8％ and 33.2％ in high RHR group.Compared with low RHR group,the risk of carotid artery unstable plaque increased to 29％ in high RHR group after adjusting for all influencing factors.The odds ratio was 1.290 （95％ CI 1.039-1.062）.Conclusion High RHR can increase the risk of carotid artery unstable plaque in middle and advanced aged population.

关 键 词：心率 动脉粥样硬化 颈动脉 中老年 危险因素 

分 类 号：R543.4[医药卫生—心血管疾病]