血浆内脏脂肪素在非酒精性脂肪性肝病中的表达及其意义  

Clinical significance of plasmavisfatin level in patients with non-alcoholic fatty liver disease

作　　者：蔡怀阳[1] 李运泽[1] 李莉[2] 邹劲涛[3] 涂强[4] 

机构地区：[1]柳州市人民医院消化内科,广西壮族自治区柳州市545006 [2]柳州市人民医院感染科,广西壮族自治区柳州市545006 [3]柳州市人民医院核医学科,广西壮族自治区柳州市545006 [4]柳州市人民医院体检部,广西壮族自治区柳州市545006

出　　处：《世界华人消化杂志》2014年第19期2763-2767,共5页World Chinese Journal of Digestology

基　　金：广西柳州市科学技术局健康安全技术开发与应用研究基金资助项目;No.2008031423~~

摘　　要：目的:探讨非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者与健康人群血,浆内脏脂肪素水平的变化及其意义.方法:选择进行健康体检的人员共170例;分成两组:即非酒精性脂肪性肝病组110例(分轻度40例、中度40例和重度30例),健康对照组60例.入选者空腹检查血压、身高、体质量、臀围、腰围、甘油三脂、总胆固醇、血糖、肝功能、胰岛素水平和内脏脂肪素测定,计算体质量指数(body mass index,BMI)、腰臀比(waist-hip ratio,WHR),并用稳态模型评估的胰岛素抵抗指数(homeostasis model assessment,HOMA-IR).结果:(1)健康对照组与非酒精性脂肪性肝病组比较,BMI、WHR、内脏脂肪素、收缩压、舒张压、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、HOMAIR等指标差异存在统计学意义(P<0.05).内脏脂肪素在轻度、中度、重度NAFLD中依次升高,轻度非酒精性脂肪性肝病组与中重度非酒精性脂肪性肝病组差异有统计学意义;(2)相关分析显示,内脏脂肪素与BMI、WHR、HOMA-IR等呈正相关,随脂肪肝加重,其相关性更强(r值依次为0.557、0.398,0.508;0.579,0.508,0.650,均P<0.05).结论:NAFLD患者血浆内脏脂肪素水平明显高于健康人群.随着NAFLD的加重,血浆内脏脂肪素水平逐渐升高.内脏脂肪素与NAFLD关系密切,其可能在NAFLD的发病过程中起一定作用.AIM： To detect plasma visfatin level in patients with non-alcoholic fatty liver disease and to ana-lyze its significance.METHODS： One hundred and seventy sub-jects were enrolled in the study, including 110 cases of non-alcoholic fatty liver disease and 60 cases of healthy controls. Blood pressure（BP）, height, weight, waist circumference（WC）, hip, body mass index（BMI）, waist-hip ratio（WHR）, triglyceride（TG）, total cholesterol（TC）, fasting blood glucose, fasting insulin, liver function and plasma visfatin were measured in each patient and the HOMA-IR was calculated according to the typical HOMA model. RESULTS： The visfatin level, BMI, WHR, SBP, DBP, ALT, AST and HOMA-IR were significant-ly higher in the patient group than in the normal control group（P〈0.05 for all）. Plasma visfatin levels were significantly positively correlated with BMI, WHR and HOMA-IR, and the correla-tions became more significant with the aggrava-tion of non-alcoholic fatty liver disease（r = 0.557, 0.398, 0.508, 0.579, 0.508, 0.650, P〈0.05 for all）. CONCLUSION： Plasma visfatin levels were sig-nificantly higher in patients with non-alcoholic fatty liver disease, which increased with the ag-gravation of the disease. There was an important correlation between plasma visfatin and non-alcoholic fatty liver disease, which implied that plasma visfatin may play a role in the pathogen-esis of this disease.

关 键 词：非酒精性脂肪性肝病 内脏脂肪素 

分 类 号：R575.5[医药卫生—消化系统]