湖北宜城地区双价肾综合征出血热灭活疫苗接种前后抗体水平调查  

Investigation on serum antibody level after immunization with HFRS in Yicheng city,Hubei province

作　　者：彭延[1] 邹文菁[1] 李国明[1] 江永忠[1] 

机构地区：[1]湖北省疾病预防控制中心,武汉430079

出　　处：《公共卫生与预防医学》2014年第4期39-41,共3页Journal of Public Health and Preventive Medicine

摘　　要：目的评价湖北省大规模预防接种双价肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)疫苗免疫效果,为以疫苗接种为主的综合防控措施在省内推广和应用提供科学依据。方法在湖北省肾综合征出血热高发区的重点人群中实施浙江卫信生物药业有限公司生产的双价HFRS疫苗接种,用酶联免疫的方法分别检测疫苗接种前后人群出血热IgG水平。结果免疫前人群HFRS IgG抗体阳性率为7.75%,在第1、2针次基础免疫后1个月,其IgG抗体阳性率为68.00%,第3针次加强免疫后1个月,其IgG抗体阳性率为76.00%。结果表明实施HFRS疫苗接种后,人群IgG抗体水平显著增加。结论在肾综合征出血热高发区大规模采取疫苗预防接种是见效最快、最安全、效果最显著的疾病防制措施。Objectives To observe the changes in serum antibody level after mass immunization with vaccine againsthemorrhagic fever with renal syndrome （HFRS） and evaluate the effectiveness in the prevalent areas, so as to provide basisfor the new vaccinebased prevention strategy. Methods HFRS bivalent vaccines produced by Zhejiang Tianyuan Bio-pharmaceutical Company were inoculated among the susceptible people in high epidemic areas in Hubei province. SpecificIgG antibody was determined with ELISA. Results The IgG positive rate was 7.75% before vaccination. In a monthafter the basic immunization, the sero-conversion rate was 68.00%, and in a month after the strengthened immunization,the sero-conversion rate was up to 76.00%. Conclusion The antibody level significantly increased after vaccination, itproved that the vaccine prevention strategy was a fast, safe, and effective measure for the prevention and control ofhemorrhagic fever with renal syndrome in the prevalent areas.

关 键 词：肾综合征出血热 疫苗 IGG抗体 

分 类 号：R186[医药卫生—流行病学]