肝肾移植术后他克莫司血药浓度影响因素的研究  

Study on influencing factors of tacrolimus blood concentrations after liver or kidney transplantation

作　　者：刘丽娟[1] 赖雁威 周学琴[1] 

机构地区：[1]北京大学深圳医院药剂科,广东518036

出　　处：《齐齐哈尔医学院学报》2014年第16期2360-2362,共3页Journal of Qiqihar Medical University

基　　金：深圳市科技创新委员会资助课题

摘　　要：目的：基于临床治疗过程的角度，研究影响他克莫司谷浓度的因素，为临床调整服药剂量提供参考。方法以肝肾移植术后患者为研究对象，服药后9～16小时测定血液中他克莫司谷浓度，分析谷浓度与可能的影响因素之间的关系。结果肾移植术后血药浓度高于肝移植术后，30～39岁年龄段血药浓度最高，女性血药浓度低于男性，服药剂量与血药浓度相关系数r分别为肝＝0．406，肾＝0．639。结论肝肾移植术后、性别、年龄、药物调整次数和服药剂量等都会影响他克莫司血药浓度。合并用药有利于控制血药浓度。服药剂量与谷浓度在一定范围内有相关。Objective To study the factors affecting the concentration of tacrolimus valley and provide reference for clinical adjustment dose based on the angle of the clinical treatment process .Methods Patients after taking kidney transplantation as the research object , test the concentration of tacrolimus valley in the blood after taking the drug 9～16 hours later , and analyzed the relationship between the valley concentration and the possible influencing factors .Results The blood drug concentration after renal transplantation was higher than that after liver transplantation .People between 30 and 39 had the highest blood drug concentration;women＇s blood concentrations were less than men＇s.The dosage and the blood drug concentration correlation coefficient r of liver and was 0.406 and 0.639 respectively.Conclusions After kidney transplantation, gender, age, dose and drug adjustments will affect the tacrolimus blood concentrations . Drug combination helps control blood drug concentration.Dose is closely related to valley concentration in certain range .

关 键 词：肝移植术后 肾移植术后 他克莫司 谷浓度 影响因素 

分 类 号：R699.2[医药卫生—泌尿科学]