Biased ligand bonds to make right calls—laboratory of signal transduction reveals molecular mechanism for functional selectivity of GPCR  

作　　者：WANG Jue 

机构地区：[1]Institute of Molecular Medicine, Peking University

出　　处：《Science China(Life Sciences)》2014年第9期957-958,共2页中国科学（生命科学英文版）

摘　　要：In a recent study, Professor Rui-Ping Xiao and her research group at Institute of Molecular Medicine of Peking Univer- sity has provided an essential experimental evidence to support the new paradigm of functional selectivity for G protein-coupled receptor （GPCR） signal transduction. The study was published online on May 15 in The Journal of Biological Chemistry [ 1 ].In a recent study,Professor Rui-Ping Xiao and her research group at Institute of Molecular Medicine of Peking University has provided an essential experimental evidence to support the new paradigm of functional selectivity for G protein-coupled receptor(GPCR)signal transduction.The study was published online on May 15 in The Journal of Biological Chemistry[1].The GPCR superfamily,a class of membrane

关 键 词：G蛋白偶联受体 信号转导 功能选择 分子机制 配体 实验证据 分子医学 生物化学 

分 类 号：R3411[医药卫生—基础医学]