长沙地区健康成年居民胃蛋白酶原参考范围的建立  

Establishment of pepsinogen reference intervals of healthy population in Changsha area

作　　者：李海英[1] 左灿[1] 王艳兰[1] 卿之驹[1] 

机构地区：[1]中南大学湘雅二医院检验科,湖南长沙410011

出　　处：《国际检验医学杂志》2014年第12期1575-1576,1579,共3页International Journal of Laboratory Medicine

摘　　要：目的建立长沙地区健康成年人血清中胃蛋白酶原(PG)的参考值范围,并探讨其分布规律及相关影响因素。方法利用乳胶增强免疫比浊法对长沙地区1 279例健康人进行血清中PGⅠ和PGⅡ浓度的测定,并计算PGⅠ/PGⅡ。结果1 279例健康成年居民血清中PGⅠ、PGⅡ和PGⅠ/PGⅡ均呈偏态分布。男性血清PGⅠ浓度为62.0ng/mL、PGⅠ/PGⅡ为4.3,女性分别为59.4ng/mL、4.1,均低于男性,差异有统计学意义(P<0.05),PGⅡ的浓度与年龄呈正相关(r=0.278,P<0.01),PGⅠ/PGⅡ值与年龄呈负相关(r=-0.173,P<0.01)。男性健康成年居民血清中PGⅠ、PGⅡ和PGⅠ/PGⅡ的95%正常参考范围分别为:≥56.8ng/mL、≤22.6ng/mL、≥3.3;女性健康成年居民PGⅠ、PGⅡ和PGⅠ/PGⅡ的95%正常参考范围分别为:≥51.4ng/mL、≤23.1ng/mL、≥3.0。结论长沙地区居民血清PG水平呈明显偏态分布,受性别、年龄影响,建立当地的血清PG参考范围有助于临床对胃相关疾病的筛查与诊断。Objective To establish the reference intervals of serum pepsinogen（PG）in healthy adults in Changsha area,and to explore their distribution as well as related factors.Methods Serum PGⅠand PGⅡ levels were determined by a latex-enhanced turbidimetric immunoassay method in 1 279 subjects from Changsha area.Then PGⅠ/PGⅡ was calculated.Results The PGⅠ, PGⅡ and PGⅠ/PGⅡ levels of 1 279 healthy adult residents showed a skew distribution.The levels of serum PGⅠand PGⅠ/PGⅡ in males were 62.0 ng/mL and 4.3,which in females were 59.4 ng/mL and 4.1,significantly lower than those in males（P〈0.05）.Age was significantly positive correlated with serum concentrations of PGⅡ（r= 0.278,P〈0.01）,and was negative correla-ted with PGⅠ/PGⅡratio（r= -0.173,P〈0.01）.The normal reference ranges of serum PGⅠ,PGⅡ and PGⅠ/PGⅡ in males were≥56.8 ng/mL,≤22.6 ng/mL,and ≥3.3,respectively,and in females were ≥51.4 ng/mL,≤23.1 ng/mL,and ≥3.0,respec-tively.Conclusion The serum PG levels of healthy adult residents significantly show skew distributions in Changsha area,which are affected by gender and age.The establishment of reference intervals of PG contributes to clinical screening and diagnosis of gas-tric-related deseases.

关 键 词：胃蛋白酶原 健康成年居民 参考范围 乳胶增强免疫比浊法 

分 类 号：R446.6[医药卫生—诊断学]