血清1,5-脱水葡糖醇测定对糖尿病血管损伤的诊断价值  

Diagnosis significance of serum1,5-anhydroglucitol for vascular injury of diabetes mellitus

作　　者：张丽[1] 安恒庆[1] 许大成[1] 刘萍丽[1] 司志娟[1] 张朝霞[1] 

机构地区：[1]新疆医科大学第一附属医院医学检验中心,新疆乌鲁木齐830054

出　　处：《国际检验医学杂志》2014年第12期1620-1621,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清1,5-脱水葡糖醇(1,5-AG)在糖尿病血管损伤期的诊断价值。方法将133例患者分为糖尿病组81例(包括单纯2型糖尿病25例、2型糖尿病视网膜病变44例和糖尿病肾脏病变12例)和非糖尿病组52例(包括视网膜病变28例和肾脏病变24例),测定血清葡萄糖和血清1,5-脱水葡糖醇。绘制受试者工作特征(ROC)曲线,计算血糖(Glu)和1,5-AG诊断糖尿病血管损伤的敏感性、特异性、约登指数和曲线下面积。结果糖尿病组血清Glu水平明显高于非糖尿病组(P<0.05),糖尿病组血清1,5-AG水平明显低于非糖尿病组(P<0.05)。ROC曲线分析结果显示,Glu诊断糖尿病血管损伤的最佳临界点为5.145 0mmol/L,敏感性为88.9%,特异性为90.4%,约登指数为0.792 7,ROC曲线下面积为0.933 0。血清1,5-AG诊断糖尿病血管损伤的最佳临界点为98.650 0μmol/L,敏感性为92.6%,特异性为96.2%,约登指数为0.887 5,ROC曲线下面积为0.980 0。结论血清1,5-AG对糖尿病血管损伤的诊断性能优于Glu,具有重要的临床意义。Objective To investigate the diagnosis significance of serum 1 ,5-anhydroglucitol（1 ,5-AG）for diabetes mellitus with vascular injury.Methods A total of 133 patients were classified into diabetes mellitus（DM）group（81 cases）and non-DM group （52 cases）.DM group included type 2 diabetes mellitus（25 cases）,diabetic retinopathy（44 cases）and diabetic nephropathy（12 ca-ses）,while non-DM group included retinopathy（28 cases）and nephropathy（24 cases）.Receiver operating characteristic（ROC） curve was set up,and the sensitivity,specificity,Youden index and area under the curve（AUC）were analyzed for glucose（Glu）and 1,5-AG.Results Serum Glu level in DM group was significantly higher than that in non-DM group（P〈0.05）and 1,5-AG level in DM group was significantly lower than that in non-DM group（P〈0.05）.According to ROC curve,it approved that the best cut-off point of Glu and 1,5-AG might be 5.145 0 mmol/L and 98.650 0μmol/L respectively.It was figured out that the sensitivities of Glu and 1,5-AG were respectively 88.9% and 92.6%,the specificities were 90.4% and 96.2%,the Youden indexes were 0.792 7 and 0.887 5,the ROC AUC were 0.933 0 and 0.980 0.Conclusion Serum 1,5-AG has clinical significance in vascular injury of dia-betes mellitus diagnosis,and is a better marker than Glu.

关 键 词：1  5-脱水葡糖醇 葡萄糖 糖尿病 血管损伤 

分 类 号：R587.2[医药卫生—内分泌]