One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-α]pyridines Under Solvent-free Conditions  

作　　者：ZONG Chenglong ZENG Runsheng ZOU Jianping 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P R. China

出　　处：《Chemical Research in Chinese Universities》2014年第4期632-638,共7页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（Nos.20772088, 21172163） and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

摘　　要：A direct and efficient approach to synthesize imidazo[1,2-α]pyridines through three-component one-pot reaction of 2-aminopyridine,aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed.This method provides a rapid access to substituted imidazo[1,2-α]pyridines with good yields（up to 85％）.A direct and efficient approach to synthesize imidazo[1,2-α]pyridines through three-component one-pot reaction of 2-aminopyridine,aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed.This method provides a rapid access to substituted imidazo[1,2-α]pyridines with good yields（up to 85％）.

关 键 词：Copper nanoparticle Three-component reaction Solvent-free condition 2-AMINOPYRIDINE ALDEHYDE ALKYNE 

分 类 号：TQ457.29[化学工程—农药化工] TQ244.2