联合应用顺阿曲库铵与维库溴铵后ED_(50)和ED_(95)的改变  

The change of ED_(50) and ED_(95) for combination of cisatracurium and vecuronium

作　　者：葛培青[1,2] 叶照君[1,2] 陶伟平[1,2] 梁伟民[3] 

机构地区：[1]上海市静安区中心医院 [2]复旦大学附属华山医院静安分院麻醉科,上海200040 [3]复旦大学附属华山医院麻醉科,上海200040

出　　处：《中国当代医药》2014年第24期142-144,共3页China Modern Medicine

基　　金：上海市静安区卫生系统"十;百;千"人才建设工程项目(201006c003)

摘　　要：目的：观察顺式阿曲库铵联合维库溴铵用药后ED50和ED95的变化。方法将75例择期手术患者（ASAⅠ~Ⅱ级）随机分为3组：顺式阿曲库铵组、维库溴铵组和顺式阿曲库铵＋维库溴铵组，每组各25例。麻醉诱导后，以单次给药法观察起效时间和T1达到最大抑制的时间，描绘3组患者的量-效曲线，求得各自的ED50和ED95值，并运用等效图法和代数法对两药相互作用进行分析。结果单用顺式阿曲库铵组、维库溴铵组ED50值分别为32.35、28.78μg/kg，ED95值分别为52.67、51.20μg/kg。联合用药时ED50值为16.81、12.17μg/kg，ED95值为23.49、22.16μg/kg，与单独用药相比，差异均有统计学意义。联合用药时ED50和ED95的合用代数值分别为0.942、0.879。结论联合使用顺式阿曲库铵和维库溴铵具有协同作用，且量-效曲线产生左移。Objective To observe the change of ED50 and ED95 for the treatment with cisatracurium and vecuronium. Methods 75 cases of patients undergoing elective surgery （ASA Ⅰ to II level） were ramdomly divided into three groups：cisatracurium group,vecuronium group and cisatracurium＋vecuronium group,each group of 25 cases.The onset time and T1 maximum inhibition time were determined by the single-injection doseresponse technique after anesthesia induction.Their respective ED50 of ED95 values were caculated by the depicted dose-response curve among the three groups of patients.The two medicine interaction analysis was caculated by the equivalent diagram method and algebraic method. Results ED50 was 32.35,28.78 μg/kg and ED95 was 52.67,51.20 μg/kg when patients were given single dose of atracurium or vecuronium.ED50 was 16.81,12.17 μg/kg and ED95 was 23.49,22.16 μg/kg when it combined the both two groups.Compared with other group,the differences in cisatracurium＋vecuronium group were statistically significant.The combinational value of ED50 and ED95 was 0.942 and 0.879,respectively. Conclusion The combination of cisatracurium and vecuronium produces synergy effect and shifts the dose-response curve to the left.

关 键 词：维库溴铵 顺式阿曲库铵 ED50 ED95 

分 类 号：R614[医药卫生—麻醉学]