2型糖尿病合并下肢血管病变患者血糖波动与超敏C反应蛋白的相关性研究  

Relationship between the Blood Sugar Fluctuation with High Sensitivity C Reactive Protein in Type 2 Diabetes Patients with Lower Extremity Vascular Disease

作　　者：彭永[1,2] 吕肖锋[1] 王亚双[1] 程千鹏[1] 赵晶[1] 张星光[1] 武晋晓[1] 丁林[1] 陈少敏[1] 

机构地区：[1]北京军区总医院内分泌科,北京100700 [2]安徽医科大学研究生学院,合肥230032

出　　处：《解放军医药杂志》2014年第8期25-28,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：国家科技重大专项子课题(2011ZX09307-001-08)

摘　　要：目的探讨2型糖尿病(T2DM)合并下肢血管病变(diabetic lower extremity arterial disease,DLEAD)患者血糖波动与超敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)的相关性。方法选择2013年4月—2014年1月就诊于北京军区总医院内分泌科的T2DM 60例,分为单纯T2DM组(T2DM组)与合并DLEAD组(DLEAD组),每组30例。检测两组hs-CRP;应用动态血糖监测系统(monitored continuous glucose monitoring system,CGMS)行连续72 h血糖监测,比较两组日内平均血糖波动幅度(mean amplitude of glycemic excursions,MAGE)与全天血糖标准差(standard deviation of blood glucose,SDBG);分析hs-CRP与血糖波动参数及临床生化指标的相关性。结果 DLEAD组MAGE、SDBG、hs-CRP比T2DM组均明显升高(P<0.05)。HbA1c、SDBG、MAGE与hs-CRP呈显著正相关(r=0.494、0.333、0.57,P<0.05),SDBG、HbA1c与hs-CRP呈独立相关(Y=1.923+0.622HbA1c+0.961SDBG)。结论T2DM合并DLEAD患者的血糖波动与hs-CRP密切相关,可能通过诱发体内炎症反应引起DLEAD的发生、发展。Objective To investigate the relationship between the blood sugar fluctuations with high sensitivity C reactive protein （hs-CRP） in type 2 diabetes patients （T2DM） with deep lower extremity vascular diseases （DLEAD）. Methods A total of 60 patients with T2DM during April 2013 and January 2014 in Department of Endocrinology were di-vided into patients with T2DM group （group A, n=30） and patients with T2DM complicated with lower extremity vascu-lar diseases group （group B, n=30）. The levels of hs-CRP in the two groups were detected respectively; blood sugar monitoring was also performed by continuous glucose monitoring system （ CGMS） for 72 h in the two groups, and the val-ues of mean amplitude of glycemic excursions （ MAGE ） and standard deviation of blood glucose （ SDBG ） in the two groups were compared;the relationship between the clinical biochemical indexes and blood sugar parameters with hs-CRP level was analyzed. Results The levels of MAGE, SDBG and hs-CRP in group B were significantly higher than those in group A （P〈0. 05）. The levels of HbA1c, SDBG and MAGE was positively related to hs-CRP level （ r =0. 494, 0. 333, 0. 57, P〈0. 05）; the levels of SDBG and HbA1c was independently related to hs-CRP level （ Y=1. 923 ＋0. 622HbA1c＋0. 961SDBG）. Conclusion Blood sugar fluctuations is closely related to hs-CRP level in T2DM patients with DLEAD, and it may cause or aggravate diabetic lower extremity vascular disease by inducing inflammatory reaction in vivo.

关 键 词：糖尿病 2型 下肢血管病变 血糖波动 超敏C反应蛋白 

分 类 号：R587.29[医药卫生—内分泌]