山茱萸多糖软胶囊的制备工艺  

Preparation Technology of Comus Polysaccharides Soft Capsule

作　　者：赵艳艳[1] 詹政军 郭利军[1] 

机构地区：[1]商洛学院生物医药与食品工程学院,陕西商洛726000

出　　处：《商洛学院学报》2014年第4期12-14,共3页Journal of Shangluo University

基　　金：国家级大学生创新创业训练计划项目(20131139602)

摘　　要：为了研制山茱萸多糖软胶囊,以山茱萸为原材料,采用水提醇沉法制备山茱萸多糖,并筛选内容物中的主药与分散剂、吸附剂的比例,以内容物均匀度、流动性和沉降体积比为考察指标,确定山茱萸多糖软胶囊处方及制备工艺。结果表明,以聚乙二醇(PEG-400)为分散剂,食用植物油为吸附剂,聚甘油酯为乳化剂,蜂蜡为助悬剂,维生素E为增强剂制得的内容物处方最稳定。该工艺质量可控,适合于工业生产。To develop preparation technology of comus polysaccharides soft capsule, with comus production as raw material, polysaccharides was extracted with water extraction and alcohol precipitation. Preparation technique is systematically clone by screening, including the shell composition of the soft capsule, the diluent of contents, and to content uniformity, liquidity and sedimentation volume as examining index. The prescription containing polyethylene glycol （PEG - 400） as dispersant, oil as adsorbent, polyethylene glyceride as emulsifier, beeswax as suspended aid, Vitamin E for strengthening agent,and the prescription showed the best stability. The preparation technology is stable and the quality is controllable. It is suitable for industrial production.

关 键 词：山茱萸多糖 软胶囊 流动性 沉降体积比 

分 类 号：R285[医药卫生—中药学]