五藤二草汤治疗活动期类风湿关节炎临床研究  

Clinical Study on Wuteng Ercao Decoction in Treating Active Rheumatoid Arthritis

作　　者：罗勇[1] 呼永河[1] 郭明阳[1] 杨敏[1] 张俊[1] 贠明东[1] 

机构地区：[1]中国人民解放军成都军区中西医结合风湿病诊治中心,四川成都610083

出　　处：《中国中医药信息杂志》2014年第9期33-35,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：成都军区总医院院管课题(2013YG-C004)

摘　　要：目的观察五藤二草汤对活动期类风湿关节炎(RA)的临床疗效及其对白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的影响。方法将65例活动期RA患者随机分为对照组(32例)和治疗组(33例)。对照组口服甲氨蝶呤片10 mg,每周1次;硫酸羟氯喹片200 mg,每日2次;双氯芬酸钠缓释片75 mg,每日2次。治疗组在对照组的基础上加用五藤二草汤,每日3次,口服。疗程12周。于治疗后观察临床疗效和实验室指标变化及不良反应情况。结果治疗后2组关节疼痛数、关节肿胀数较治疗前显著好转(P<0.05),治疗后关节疼痛数2组比较差异有统计学意义(P<0.05)。治疗后患者评分、医生评估优于治疗前(P<0.05),2组比较差异有统计学意义(P<0.05)。治疗后红细胞沉降率、C反应蛋白、IL-6、TNF-α水平显著降低(P<0.05),治疗组改善优于对照组(P<0.05)。治疗组不良反应2例,对照组1例。结论五藤二草汤治疗活动期RA疗效显著,且能下调IL-6及TNF-α水平。Objective To observe the e/tlcacy at Wuteng Ercao decoction in treating actlve rheumatoid arthritis （RA） and its effects on the levels of cytokine interleukin-6 （IL-6） and tumor necrosis factor-a （TNF-α）. Methods Sixty-five patients with active RA were randomly divided into treatment group （33 cases） and control group （32 cases）. Patients in the control group were administered with methotrexate tablets 10 mg, oral taking, once a week; hydroxychloroquine sulfate tablets 200 mg, oral taking, twice a day; diclofenac sodium sustained release tablets 75 mg, oral taking, twice a day. Patients in the treatment group were administered with Wuteng Ercao decoction additionally, oral taking, three times a day. The treatment lasted for 12 weeks. The changes and untoward effects of various clinical and laboratory indicators were observed before and after treatment. Results After treatment, the tender joint count, swollen joint count, patient＇s global assessment, and physician＇s global assessment were improved （P〈0.05）, with statistical significance between the two groups （P〈0.05）. The levels of ESR, CRP, IL-6 and TNF-α decreased significantly after treatment （P〈0.05）, but those were more significantly in treatment group （P〈 0.05）. There were 2 cases with untoward effects in the treatment group and 1 case in the control group （P〉0.05）. Conclusion Wuteng Ercao decoction is effective in patients with active RA and it can reduce the levels of IL-6 and TNF-u.

关 键 词：五藤二草汤 类风湿关节炎 C反应蛋白 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R259.932.2[医药卫生—中西医结合]